Use of chimeric CD4-src protein tyrosine kinases in drug screeni

Details Use of chimeric CD4-src protein tyrosine kinases in drug screeni Use of chimeric CD4-src protein tyrosine kinases in drug screeni

1995-06-02

1997-09-23

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 15, 435 697, C12Q 168

Patent

active

056703244

ABSTRACT:
The present invention provides chimeric proteins containing extracellular and transmembrane domains of CD4 and protein tyrosine kinases of the src family. Also provided are DNA molecules encoding the proteins of the present invention and cells containing such DNA molecules. The proteins and cells of the present invention may be employed in methods for identifying drugs that block T cell activation and for identifying low level self-antigens.

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