Use of chemical chelators as reversal agents for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S176000, C514S308000, C514S547000

Reexamination Certificate

active

10049393

ABSTRACT:
The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) wherein R is (a), (b) or (c); or general formula (B) wherein X is (a), (b) or (d), or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3929813 (1975-12-01), Higuchi et.al.
patent: 5180716 (1993-01-01), Yaksh et al.
patent: 5767112 (1998-06-01), Poli et al.
patent: 5834446 (1998-11-01), Dow et al.
patent: 5840881 (1998-11-01), Uda et al.
patent: 36628 95 (1996-05-01), None
patent: 0 447 171 (1991-09-01), None
patent: 11-246603 (1999-09-01), None
Bom, A. et al “A novel concept of reversing neuromuscular block” Angew. Chem. Int. Ed. (2002) vol. 41, no 2, pp. 266-270.
Adam, J. et al “Cyclodextrin-derived host molecules as reversal agents . . . ” J. Med. Chem. (2002) vol. 45, pp 1806-1816.
Tarver, G. et al “2-O-Substituted cyclodextrins as reversal agents . . . ” Bioorg. Med. Chem. (2002) vol. 10, pp 1819-1827.
Zhang, M. “Drug-specific cyclodextrins . . . ” Drugs of the Future (2003) vol. 28, no 4, pp 347-354.
Lee, C. “Structure, conformation, and action of neuromuscular blocking drugs” Brit. J. Anesth. (2001) vol. 87, no 5, pp 755-769.
B Desire: “Inactivation of sarin and soman by cyclodextrins in vitro” EXPERIENTIA, vol. 43, No. 4, 1987, pp. 395-397.
B. Desire: “Interaction of soman with beta-cyclodextrin” Fundamental and Applied Toxicology, vol. 7, No. 4, 1986, pp. 647-657.
C. May: “Development of a toxin-bindng agent as a treatment for tunicamycinuracil toxicity: protection against tunicamycin poisoning of sheep” Australian Veterinary Journal, vol. 76, No. 11, 1998 pp. 752-756.
K. Uekama: “Effects of cyclodextrins on chlorpromazine-induced haemolysis and nervous systems responses” J. Pharm. Pharmacol., vol. 33, No. 11, 1981, pp. 707-710.
T. Irie: “Protective mechanism of beta-cyclodextrin for the hemolysis induced with phenothiazine neuroleptics in vitro” J. Pharmacobio-Dynamics, vol. 6, No. 6, 1983, pp. 408-414.
International Search Report No. PCT/EP 00/07694 dated Jul. 20, 2001.
Stella, V.J. et al. “Cyclodextrins: Their Future in Drug Formulation and Delivery,” Pharmaceutical Research, vol. 14, No. 5 (1997), pp. 556-567.
Uekama, K. et al. “Cyclodextrin Drug Carrier Systems,” Chem. Rev. (1998) vol. 98, pp. 2045-2076.
Khan, A. R. et al. “Methods for Selective Modifications of Cyclodextrins,” Chem. Rev. (1998) vol. 98, pp. 1977-1996.
Szente, L. et al. “Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development,” Advanced Drug Delivery Reviews (1999) vol. 36, pp. 17-28.
Gattuso, G. et al. “Synthetic Cyclic Oligosaccharides,” Chem. Rev. (1998) vol. 98, pp. 1919-1958.
Miyake, M. et al. “Anionic Cyclophanes as Hosts for Cationic Aromatic Guests,” Tetrahedron Letters, vol. 32, No. 49 (1991) pp. 7295-7298.
Miyake, M. et al. “Biomimetic Studies Using Artificial Systems. VI.1)Design and Synthesis of Novel Cyclophanes Having Eight Carboxyl Groups on the Aromatic Rings2),” Chem. Pharm. Bull., vol. 41(7) (1993) pp. 1211-1213.
Cram, D. J. et al. Macro Rings. VIII. Aromatic Substitution of the [6.6] Paracyclophane1, JAm. Chem. Soc. (1955) vol. 77, pp. 1179-1186.
Soga, T. et al. “Modifications of Hydrophobic Cavity and their Effects on the Complex Formation with a Hydrophobic Substrate,” Tetrahedron Letters, vol. 21 (1980) pp. 4351-4354.
Golden, J.H. “Bi(anthracene-9, 10-dimethylene) (Tetrabenzo-[2,2]-para-cyclophane].,” J. Chem. Soc. (1961) pp. 3741-3748.
Ashton, P. R. et al. “Synthetic Cyclic Oligosaccharides—Syntheses and Structural Properties of a Cyclo[1→4)-α-L-rhamnopyranosyl-(1→4)-α-D-mannopyranosyl] trioside and -tetraoside**,” Chem. Eur. J. (1996) vol. 2, No. 5, pp. 580-591.
Loukas, Y. L., “Measurement of Molecular Association in Drug: Cyclodextrin Inclusion Complexes with Improved1H NMR Studies,” J. Pharm. Pharmacol (1997) vol. 49, pp. 944-948.
Bisson, A. P. et al. “Cooperative Interactions in a Ternary Mixture,” Chem. Eur. J. (1998) vol. 4, No. 5, pp. 845-851.
Jicsinszky, L. et al., “Cyclodextrin Derivatives,” Comprehensive Supramolecular Chemistry, vol. 3, Cyclodextrins, Elsevier Science Ltd., Oxford, UK (1996) pp. 57-188.
Vogtle et al.j, “Cyclophane Hosts: Endoacidic, Endobasic, and Endolipophilic Large Cavities,” Comprehensive Supramolecular Chemistry, vol. 2, Molecular recognition: Receptors for molecular guests, Atwood et al. eds; Elsevier Science Ltd., Oxford, UK (1996) pp. 211-265.
Connors, K.A. “Binding constants, The measurement of Molecular Complex Stability,” Wiley-Interscience, New York (1987) pp. 24-28.
Gennaro, A. R. et al “Parental preparations,” Chapter 84, Remington's Pharmaceutical Sciences, 18thed., Mack Publishing Company (1990) pp. 1545-1569.
Gennaro, A. R. et al “Intravenous admixtures,” Chapter 85, Remington's Pharmaceutical Sciences, 18thed., Mack Publishing Company (1990) pp. 1570-1580.
Patent Abstracts of Japan Translation of JP 11-246603.
Kuroda, Y. et al., “Dynamic Molecular Motions of ρ-Methylcinnamic Acid Included into β-Cyclodextrin Derivatives: A New Type of Free-energy Relationship in Complex Formation,” J. Chem. Soc. Perkin Trans. II, vol. 10 (1989) pp. 1409-1415.
Guillo, F. et al., “Synthesis of symmetrical cyclodextrin derivatives bearing multiple charges,” Bull. Soc. Chim. Fr., vol. 132 (1995) pp. 857-866.
Baer, H. et al., “Heptakis [6-S-(2,3-dihydroxypropyl)-6-thio]cyclomaltoheptaose and its sulfone: water-soluble β-cyclodextrin derivatives having modified polarity,” Carbohydrate Research, vol. 280 (1996) pp. 315-321.
Lindberg B. et al., “Synthesis of some 2-0-(2-hydroxyalkyl) and 2-0-(2,3-di-hydroxyalkyl) derivatives of cyclomaltopheptaose,” Carbohydrate Research, NL, Elsevier Scientific Publishers B.V., Amsterdam vol. 222, No. 1 (1991) pp. 113-119.
Khan A. R. et al., “Methods for Selective Modifications of Cyclodextrins,” Chemical Reviews, US, American Chemical Society, Easton, vol. 98, No. 5, (1998) pp. 1977-1996.

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