Use of charged phospholipids to reduce nanoparticle aggregation

Details Use of charged phospholipids to reduce nanoparticle aggregation Use of charged phospholipids to reduce nanoparticle aggregation

1992-12-11

1994-08-09

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 4, 424484, 424493, 424497, 514568, A61K 914

Patent

active

053365070

ABSTRACT:
This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

REFERENCES:
patent: 4894234 (1990-01-01), Sharma et al.
patent: 4904479 (1990-02-01), Illum
patent: 5091188 (1992-02-01), Haynes
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5151264 (1992-09-01), Samain et al.
patent: 5188837 (1993-02-01), Domb
patent: 5396630 (1983-08-01), Riedl et al.

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