Use of charged nitroxides as NMR image enhancing agents for CSF

Details Use of charged nitroxides as NMR image enhancing agents for CSF Use of charged nitroxides as NMR image enhancing agents for CSF

1986-03-07

1989-05-30

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 4, 128653, 128654, 436173, 436806, 600 12, A61K 4900, A61B 505, A61B 600

Patent

active

048349640

ABSTRACT:
Charged, stable, organic nitroxides, e.g., charged by a quaternary ammonium or a Bronsted acid group, are useful as NMR image enhancing agents for cerebrospinal fluid.

REFERENCES:
patent: 4656026 (1987-04-01), Coffman et al.
Griffeth et al., Inves. Rad., vol. 19, Nov.-Dec. 1984, pp. 553-562.
Organic Chemistry, 3rd Edition, Morrison, et al., (Eds.), 1974, pp. 752-755.
Medicinal Chemistry, 2nd Edition, Burger, A. (Ed.), 1960, p. 43.
Brasch, et al., Radiology, vol. 147, (1983), pp. 773-779.
Keana, J.F.W., Chemical Reviews, vol. 78, No. 1, (1978), pp. 37-64.
Biological Magnetic Resonance, Berliner, et al., (Eds.), Plenum Press, New York, 1982, pp. 1-11.

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