Use of certain nucleoside analogs to attenuate cancer cell resis

Details Use of certain nucleoside analogs to attenuate cancer cell resis Use of certain nucleoside analogs to attenuate cancer cell resis

1989-10-13

1992-11-24

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, 514 50, 514261, 514269, A61K 3170, A61K 3152, A61K 31505

Patent

active

051661403

ABSTRACT:
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.

REFERENCES:
Kornberg, et al., "Studies on the Replication of DNA by DNA Polymerases" Cold Spring Harbor Symp. Quart. Biol. 28:9-19 (1963).
Newman, et al.,"Mechanisms of Cross-Resistance to Methotrexate and 5-fluorouracil in an A2780 Human Ovarian Carcinoma Cell Subline Resistant to Cisplatin", Biochemical Pharmacology 37:443-447 (1988).
Scanlon, et al, "Overexpression of DNA Replication and Repair Enzymes in Cisplatin-Resistant Human Colon Carcinoma HCT8 Cells and Circumvention by Azidothymidine", Cancer Communications 1(4):269-275 (1989).
Scanlon, et al., "Potentiation of Azidothymidine Cytotoxicity in Cisplatin-resistant Human Ovarian Carcinoma Cells", Cancer Communications 2(10):339-343 (1990).

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