Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quin

Details Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quin Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quin

1997-08-26

1999-06-08

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

059105011

ABSTRACT:
This invention relates to the manufacture of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines and their use as medicaments in the treatment of cognitive disorders.

REFERENCES:
patent: 4845115 (1989-07-01), Tyers
patent: 4906755 (1990-03-01), Gittos
Barnes, et al., Pharmacology Biochem. & Behavior, vol. 35, 955-962 (1990).
Barnes, et al., Neuropharmacology, vol. 29 (11), 1037-1045 (Nov. 1990).
Neuropharmacology, vol. 29, No. 11, Nov. 1990, pp. 1,0237-1,045, Characterisation and Autoradiographic Localisation of 5-HT.sub.3 Receptor Forebrain of the Rat.

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