Use of certain complexed somatostatin peptides for the invivo im

Details Use of certain complexed somatostatin peptides for the invivo im Use of certain complexed somatostatin peptides for the invivo im

1995-06-06

1998-05-19

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530311, 530317, 530328, 530304, 530324, A61K 3800, C07K 708, C07K 14655, C07K 750

Patent

active

057536279

ABSTRACT:
Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.

REFERENCES:
patent: 5460785 (1995-10-01), Rhodes et al.
Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Ed., vol. 5, pp. 339-341.
European Journal of Nuclear Medicine, vol. 20, No. 8, pp. 716-731 (1993).
Mallinckrodt Nuclear Medicine OctreoSean.RTM..
Cell Biophysics, vol. 21, pp. 93-107 (1992).
Journal of Clinical Endocrinology and Metabolism, vol. 68, No. 2, pp. 239-246 (1989).

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