Use of CDP-choline for the treatment of alcohol withdrawal...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C514S050000, C514S078000, C514S274000, C514S556000

Reexamination Certificate

active

06894032

ABSTRACT:
The invention relates to the use of CDP-Choline or its pharmaceutically acceptable salts for the preparation of a medicinal product for the treatment of alcohol withdrawal syndrome at daily doses equivalent to 0.5-2 g of free CDP-Choline.

REFERENCES:
patent: 5958896 (1999-09-01), Renshaw et al.
patent: 6103703 (2000-08-01), Renshaw et al.
patent: 20020019364 (2002-02-01), Renshaw
patent: 20030220291 (2003-11-01), Renshaw
patent: 99 07385 (1999-02-01), None
patent: WO 0168104 (2001-09-01), None
“Is Ethanol a Neurotoxin?: The Effects of Ethanol on Neuronal Structure and Function”, Leonard, B.E., Alcohol Alcohol, 1986, 21(4), 325-338.*
Tornos M.E. et al., “Effect of oral CDP-choline on experimental withdrawal syndrome.”, Arzneimittel-Forschung, vol. 33, 7a, pp. 1018-11021, (1983).
Renshaw P.F., et al., “Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependant subjects: a preliminary report”, PSYCHOPHARMACOLOGY, vol. 142, no. 2, pp. 132-138, (1999).
Patt, S. Cervos-Navarro J. et al., “The effects of CDP-choline on newborn rat pups with experimental alcohol fetopathy. A Golgi study”, History and Histopathology, vol. 4, no. 4, pp. 429-434, (1989).

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