Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1998-04-29
2000-11-28
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514574, 514846, 514937, 424401, A61K 3185
Patent
active
061536490
DESCRIPTION:
BRIEF SUMMARY
The invention relates to the use of carboxylic acids carrying a thioether function, a sulphoxide function or a sulphone function, in or for the production of a cosmetic and/or dermatological composition for promoting skin desquamation and/or combating intrinsic and extrinsic skin ageing. It also relates to a non-therapeutic skin treatment process for desquamating the skin as well as to a treatment process for cutaneous ageing.
Cutaneous ageing resulting from effects of intrinsic or extrinsic factors on the skin is shown by the appearance of wrinkles and lines, and the yellowing of the skin which develops a blotchy look accompanied by the appearance of pigmentary spots, by the disorganization of the elastin and collagen fibres causing a loss of elasticity, of suppleness and of firmness and by the appearance of telangiectases.
Some of these signs of ageing are more particularly connected with intrinsic or physiological ageing, that is to say to "normal" ageing connected with age, although others are more specific for extrinsic ageing, that is to say ageing generally caused by the environment; more particularly photo-ageing due to exposure to the sun, to light or to any other radiation.
The invention is concerned with intrinsic or physiological ageing as well as with extrinsic ageing.
The changes in the skin due to intrinsic ageing are the consequence of a genetically programmed senescence in which endogenous factors intervene. This intrinsic ageing causes, especially, a slowing down of the renewal of the cells of the skin, which is essentially reflected by the appearance of clinical changes such as the reduction in the subcutaneous adipose tissue and the appearance of fine wrinkles or lines, and by histopathological changes such as an increase in the number and the thickness of the elastic fibres, a loss of vertical fibres in the membrane of the elastic tissue, and the presence of large irregular fibroblasts in the cells of this elastic tissue.
In contrast, extrinsic ageing results in clinical alterations such as thick wrinkles and the formation of a flabby and tanned skin, and in histopathological changes such as excessive accumulation of elastic matter in the upper dermis and degeneration of the collagen fibres.
Various agents intended for combating cutaneous ageing are known in the prior art.
Thus, the patent U.S. Pat. No. 4,603,146 describes the use of retinoic acid and of its derivatives in cosmetic compositions, for the purpose of combating cutaneous ageing. However, many patents and publications (see, for example, the application EP-A-0413528) as well as numerous commercial cosmetic compositions teach the use of .alpha.-hydroxy acids such as lactic acid, glycolic acid or alternatively citric acid for treating cutaneous ageing.
Finally, .beta.-hydroxy acids and more especially salicylic acid as well as its derivatives are known for their desquamating properties (see the documents WO-A-93/10756 and U.S. Pat. No. 4,767,750).
All these compounds have an action against ageing of the skin, consisting in desquamation, that is to say the elimination of "dead" cells situated at the surface of the stratum corneum. This desquamating property is also called, often wrongly, a keratolytic property. However, these compounds also have secondary effects, which consist of stinging, pulling, heating and redness, which are unpleasant for the user.
It is thus seen that the need exists for anti-ageing agents having an action which is at least as effective as that of the compounds of the prior art, but does not have their disadvantages.
The Applicant has unexpectedly found that the topical application of certain carboxylic acids carrying a thioether function, a sulphoxide function or a sulphone function, makes it possible to desquamate the skin as well as to stimulate epidermal cell renewal and epidermal repair.
Of course, carboxylic acids carrying a thioether function, a sulphoxide function or a sulphone function are already known in the cosmetic field in topical compositions for improving the elasticity of the skin (see t
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patent: 4539320 (1985-09-01), Lang et al.
patent: 4696946 (1987-09-01), Green et al.
patent: 5451405 (1995-09-01), Zhang et al.
patent: 5866168 (1999-02-01), Delacharriere et al.
"L'Oreal"
Dees Jos,e G.
Williamson Michael A.
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