Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
1998-06-16
2002-05-21
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S001110, C536S004100, C536S017200, C536S017300, C536S017400, C536S018400, C536S018500, C536S018600, C536S045000, C536S055100, C536S055200, C536S055300
Reexamination Certificate
active
06391863
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to the use of carbohydrate derivatives in or for the production of a cosmetic and/or dermatological composition for promoting skin desquamation and/or combating intrinsic and extrinsic skin ageing. It also relates to a non-therapeutic skin treatment process for desquamating the skin as well as to a non-therapeutic treatment process for cutaneous ageing.
2. Description of the Background
Cutaneous ageing resulting from effects of intrinsic or extrinsic factors on the skin is shown by the appearance of wrinkles and lines, by the yellowing of the skin which develops a blotchy look accompanied by the appearance of pigmentary spots, by the disorganization of the elastin and collagen fibres causing a loss of elasticity, of suppleness and of firmness and by the appearance of telangiectases.
Some of these signs of ageing are more particularly connected with intrinsic or physiological ageing, that is to say to “normal” ageing connected with age, although others are more specific to extrinsic ageing, that is to say ageing generally caused by the environment; more particularly photo-ageing due to exposure to the sun, to light or to any other radiation.
The invention is concerned with intrinsic or physiological ageing as well as with extrinsic ageing.
The changes in the skin due to intrinsic ageing are the consequence of a genetically programmed senescence in which endogenous factors intervene. This intrinsic ageing causes, especially, a slowing down of the renewal of the cells of the skin, which is essentially reflected by the appearance of clinical changes such as the reduction in the subcutaneous adipose tissue and the appearance of fine wrinkles or lines, and by histopathological changes such as an increase in the number and the thickness of the elastic fibres, a loss of vertical fibres in the membrane of the elastic tissue, and the presence of large irregular fibroblasts in the cells of this elastic tissue.
In contrast, extrinsic ageing results in clinical alterations such as thick wrinkles and the formation of a flabby and tanned skin, and in histopathological changes such as excessive accumulation of elastic matter in the upper dermis and degeneration of the collagen fibres.
Various agents intended for combating cutaneous ageing are known in the prior art.
Thus, the patent U.S. Pat. No. 4,603,146 describes the use of retinoic acid and of its derivatives in cosmetic compositions, for the purpose of combating cutaneous ageing.
However, many patents and publications (see, for example, the application EP-A-0413528) as well as numerous commercial cosmetic compositions teach the use of &agr;-hydroxy acids such as lactic acid, glycolic acid or alternatively citric acid for treating cutaneous ageing.
Finally, &bgr;-hydroxy acids and more especially salicylic acid as well as its derivatives are known for their desquamating properties (see the documents WO-A-93/10756 and U.S. Pat. No. 4,767,750).
All these compounds have an action against ageing of the skin, consisting in desquamation, that is to say the elimination of “dead” cells situated at the surface of the stratum corneum. This desquamating property is also called, often wrongly, a keratolytic property. However, these compounds also have secondary effects, which consist of stinging, pulling, heating and redness, which are unpleasant for the user.
It is thus seen that the need exists for anti-ageing agents having an action which is at least as effective as that of the compounds of the prior art, but does not have their disadvantages.
On the other hand, Brysk (Cell and tissue research 253, 657-663, 1988; Expl. Cell Biol. 57, 60-66, 1989) has shown the role of glycoproteins in the cohesion of the stratum corneum. She has likewise demonstrated the inhibitory action of certain carbohydrates, in particular of aminocarbohydrates, with respect to the cohesion of the stratum corneum.
The Applicant has unexpectedly discovered that certain carbohydrate derivatives show a very significant inhibitory action on the cohesion of the stratum corneum, which is greater than the action of analogous derivatives already known for this activity.
Consequently, the topical application of these novel derivatives allows the skin to be desquamated and cutaneous ageing to be combated.
Admittedly, it is known from the document U.S. Pat. No. 5,084,270 to use topically, for the treatment of dry skin, amides originating from the condensation of an acidic carbohydrate and a primary amine. However, the prior art neither mentions nor suggests a desquamating action of these products on the skin.
The document WO95/05155 describes lipophilic sugar derivatives, and their use in a cosmetic vehicle as modulators of the synthesis and/or the excretion of fibroblast elastase. However, a desquamating action of carbohydrate derivatives is neither mentioned nor suggested in this document.
SUMMARY OF THE INVENTION
The subject of the present invention is the use in or for the production of a topical composition, in the cosmetic, dermatological and/or pharmaceutical fields, of at least one carbohydrate or carbohydrate derivative corresponding to the formula (I),
R—X—A (I)
in which A is a chain formed of one to twenty carbohydrate units or carbohydrate derivative units, each comprising 3 to 6 carbon atoms, connected to each other, preferably by acetal bridges, it being possible for each of these units to be optionally substituted, for example by a halogen, by an amine function, an acid function, an ester function, a thiol, an alkoxy function, a thioether function, a thioester function, an amide function, a carbamate function or a urea function,
R is an alkyl chain or an alkenyl chain, comprising from 4 to 24 carbon atoms, which is branched or linear, it being possible for it to be interrupted by ether bridges, optionally carrying a hydroxyl function, a carboxylic acid function, an amine function, an ester function, an acyloxy function, an amide function, an ether function, a carbamate function or a urea function,
X is a function connecting R and A, such as, for example, an amine, ether, amide, ester, urea, carbamate, thioester, thioether or sulphonamide function,
for promoting the desquamation of the skin.
A subject of the invention is likewise the use of carbohydrates such as described above for combating cutaneous ageing.
DETAILED DESCRIPTION OF THE INVENTION
Preferentially, R is an alkyl chain or an alkenyl chain, comprising from 4 to 24 carbon atoms, which is branched or linear, optionally carrying a hydroxyl function.
Each of the carbohydrate units forming A can be a sugar or a sugar derivative. For example, each unit forming A can be a reduced sugar, an amino sugar or a sugar carrying a carboxylic acid function.
Among the sugars, or sugar derivatives, which can be involved in the formation of A, mention will be made, for example, of the following products, which are commercially available, optionally in salt form:
N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetylneuraminic acid, adonitol, &bgr;-D-allose, D-altrose, 6-amino-6-deoxy-D-glucose, 1,6-anhydro-glucose, arabinic acid, arabinogalactan, D-arabinose, L-arabinose, D,L-arabinose, D-arabitol, L-arabitol, D-cellobiose, D-glucosamine, D-galactosamine, 2-deoxy-D-glucose, 6-deoxy-D-galactose, 6-deoxy-L-galactose, galactitol, mesoerythritol, D-erythroe, D-fructose, D-fucose, L-fucose, D-galactaric acid, galactitol, galactomannan, D-galactono-1,4-lactone, L-galactono-1,4-lactone, D-galactosarmine, D-galactose, L-galactose, D-galacturonic acid, &bgr;-gentiobiose, glucamine, D-glucaric acid, D-glucono-1,5-lactone, L-glucono-1,5-lactone, D-glucosamine, D-glucosaminic acid, D-glucuronic acid, L-glucose, D-glucose, isomaltitol, isomaltotriose, isomaltose, lactobionic acid, D-lactose, lactulose, D-lyxose, L-lyxose, lyxosamine, maltitol, D-maltose, maltotetraose, maltotriitol, maltotriose, D-mannosamine, D-mannose, L-mannose, D-melezitose, D-melibiose, D-raffinose, D-raffinose undecaacetate, L-rhamnose, D-ribose, L-ribose, D-ribulose, rutinose, D
Ebenhan-Nappe Catherine
Philippe Michel
L'Oreal
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Wilson James O.
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