Use of calmodulin to promote bone regeneration

Details Use of calmodulin to promote bone regeneration Use of calmodulin to promote bone regeneration

2006-01-24

2006-01-24

Kunz, Gary (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S008100, C514S021800, C514S492000, C424S650000

Reexamination Certificate

active

06989368

ABSTRACT:
The present invention provides methods and compositions for promoting bone regeneration, comprising administration of calmodulin. The method of bone regeneration is applied to subjects having bone disorders characterized by decreased bone mass such as osteopenia and osteoporosis, as well as those suffering from non-union fractures.

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patent: 6287606 (2001-09-01), Bockman et al.
Fujishige et al., “Alteration of cGMP Metabolism During Chondrogenic Differentiation of Chondroprogenitor-like EC Cells, ATDC5,”Biochim. Biophys. Acta, 1452:219-227 (1999). Abstract Only.
Williams et al., “Tamoxifen Inhibits Phorbol Ester Stimulated Osteoclastic Bone Resorption: An Effect Mediated by Calmodulin,”Biochem. Cell Biol., 75:725-723 (2000). Abstract Only.
International Search Report. PCT/US02/41440, United States Patent Office as International Examining Authority.

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