Use of cabergoline and related ergoline derivatives for controll

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514913, A61K 31445

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active

057055106

ABSTRACT:
The use of certain dopaminergic compounds for controlling elevations of intraocular pressure is disclosed. The compounds are ergoline derivatives. The most preferred compound is cabergoline. The compounds have been found to produce a significant reduction of intraocular pressure.

REFERENCES:
patent: 4501749 (1985-02-01), Clineschmidt
patent: 4526892 (1985-07-01), Salvati et al.
patent: 4722933 (1988-02-01), Horn
patent: 4728649 (1988-03-01), Mantegani et al.
patent: 4774243 (1988-09-01), Baldwin
patent: 4847253 (1989-07-01), Buonamici et al.
patent: 4861793 (1989-08-01), Bernardi et al.
patent: 5110606 (1992-05-01), Geyer
patent: 5151272 (1992-09-01), Engstrom et al.
Elibol, O., et al., Intl. Ophthalmology, "The effects of dopamine, haloperidol and bromocriptine on intraocular pressure", vol. 16, pp. 343-347 (1992).
Green, et al., Exp. Eye Res., "Dopamine Stimulation of Passive Permeability and Secretion in the Isolated Rabbit Ciliary Epithelium", vol. 29, pp. 423-427 (1979).
Macri, et al., Exp. Eye Res., "The Inhibitory Actions of Dopamine, Hydroxyamphetamine and Phenylephrine on Aqueous Humor Formation", vol. 26, pp. 85-89 (1978).
Mekki, et al., The Lancet, "Bromocriptine Lowers Intraocular Pressure Without Affecting Blood Pressure", pp. 1250-1251 (1983).
Potter, et al., Curr Eye Res., "Effects of ergoline derivatives on intraocular pressure and iris function in rabbits and monkeys", vol. 2, pp. 281-288 (1983).
Potter, et al., Curr. Eye Res., "Alteration in ocular function induced by phenylethylamine analogs of dopamine", vol. 3, pp. 851-859 (1984).
Shanon, et al., Investigative Ophthalmology, "The effect of dopamine on the intraocular pressure and pupil of the rabbit eye", vol. 15, pp. 371-380 (1976).
Hutton, J. T., et al., Neurology, "Controlled study of the antiparkinsonian activity and tolerability of cabergoline", vol. 43, pp. 613-616 (1993).
Karnezis, T. A., et al., Trends In Pharmacological Science, "Dopamine receptors and intraocular pressure", vol. 9, No. 11, pp. 389-390 (1988).
Potter, D. E., et al., Current Eye Research, "Ocular hypotensive action of ergoline derivatives in rabbits: effects of sympathectomy and domperidone pretreatment", vol. 3, No. 2, pp. 307-314 (1984).
Siegal, M. J., et al., Experimental Eye Research, "Effect of Topical Pergolide on Aqueous Dynamics in Normal and Glaucomatous Monkeys", vol. 44, No. 2, pp. 227-233 (1987).
Potter, D. E., et al. Journal Of Ocular Pharmacology, "LY141865: A Relatively Selective DA.sub.2 Agonist with Complex Ocular Activity", vol. 4, No. 1, pp. 19-28 (1988).
Potter, D. E., et al., Journal of Ocular Pharmacology, "Cianergoline Lowers Intraocular Pressure in Rabbits and Monkeys and Inhibits Contraction of the Cat Nictitans by Suppressing Sympathetic Neuronal Function", vol. 3, No. 4, pp. 309-321 (1987).
Al-Sereiti, et al., Proceedings of the BPS, "The effects of a single oral dose of lisuride, terguride and bromocriptine on intraocular pressure", vol. 9, No. 11, p. 122P (Sep. 1987).
Geyer, et al., Journal of Ocular Pharmacology, "Hypotensive Effect of Bromocriptine in Normal Eyes", vol. 3, No. 1, pp. 1-4 (1987).
Geyer, et al., Journal of Ocular Pharmacology, "Hypotensive Effect of Bromocriptine in Glaucomatous Eyes", vol. 3, No. 4, pp. 291-294 (1987).
Al-Sereiti, et al., Br. J. clin. Pharmac., "A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers", vol. 28, pp. 443-447 (1989).
Mekki, et al., British Journal of Ophthalmology, "Stimulation of dopamine receptors (type 2) lowers human intraocular pressure", vol. 69, pp. 909-910 (1985).
Al-Sereiti, et al., Br. J. clin. Pharmac., "The effect of a single oral dose of pergolide on intraocular pressure and pupil diameter", vol. 28, pp. 263-268 (1989).
Al-Sereiti, et al., Br. J. clin. Pharmac., "The effects of lisuride, terguride and bromocriptine on intraocular pressure (IOP)", vol. 27, pp. 159-163 (1989).

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