Use of C1 inhibitor for the prevention of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing

Reexamination Certificate

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C530S350000

Reexamination Certificate

active

08071532

ABSTRACT:
The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.

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patent: 2003/0140358 (2003-07-01), Nuijens et al.
patent: 2005/0223416 (2005-10-01), Nuijens et al.
patent: 2006/0142220 (2006-06-01), Berkel et al.
patent: 2007/0185011 (2007-08-01), Nuijens
patent: 0157079 (2001-08-01), None
patent: 2004100982 (2004-11-01), None
C. de Zwaan, et al., “Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction”, European Heart Journal 2002, vol. 23, pp. 1670-1677.
S. Friesecke, et al., “C1-Esterase-Inhibitor als Ultima-ratio-Therapie bei volumen-und katecholaminrefraktarem Schock infolge Ischamie-Reperfusionsschaden nach langer Reanimation”, Intensivmed 2002, vol. 39, No. 7, pp. 610-616.
Marco Cicardi, et al., “C1 inhibitor: molecular and clinical aspects”, Springer Semin Immun, Nov. 3, 2005, vol. 27, pp. 286-298.
Mirela Scherer, et al., “C1-Esterase Inhibitor Reduces Reperfusion Injury After Lung Transplantation”, Ann. Thorac. Surg., 2002, vol. 73, pp. 233-239.
Claudio Storini, et al., “C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation”, Neurobiology of Disease, 2005, vol. 19, pp. 10-17.
Akita Nobuhisa, et al., “Protective Effect of C1 Esterase Inhibitor on Reperfusion Injury in the Rat Middle Cerebral Artery Occlusion Model”, Neurosurgery, Feb. 2003, vol. 52, No. 2, pp. 395-401.
DeSimoni, et al. “The Powerful Neuroprotective Action of C1-Inhibitor on Brain Ischemia-Reperfusion Injury Does Not Require C1q”.American Journal of Pathology, vol. 164, No. 5, pp. 1857-1863 May 2004.

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