Use of C1-inactivation for therapy of certain diseases

Details Use of C1-inactivation for therapy of certain diseases Use of C1-inactivation for therapy of certain diseases

1997-05-12

1999-08-17

Feisee, Lila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530830, 424 941, A61K 3843, A61K 3816

Patent

active

059393890

ABSTRACT:
The use of C1-inactivator for the production of a pharmaceutical for the prophylaxis and treatment of capillary leak syndrome (generalized extravasation) and circulator shock (refractory hypotension) in severe burns or scalds, in polytrauma, in operations under conditions of extracorporeal circulation, in the use of cytokines, endogenous mediators, and mediator hybrids and growth factors produced by genetic engineering, or capillary leak syndrome and veno-occlusive disease of the liver in therapeutically or prophylactically indicated bone marrow transplantation is described.

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patent: 5271931 (1993-12-01), Lotz et al.
H.F. Welter et al. "Versuche zur Therapie der Schoklunge mittels Superoxiddismutase (SOD) und C1-Inaktivator (C1-INA)," Langenbecks Archiv fur Chirugie, Chirurgisches Forum '85, 1985, pp. 63-67.
W. Nurnberger et al., "C1-inhibitor concentrate for sepsis-related capillary leak syndrome," Lancet, 1992, vol. 339, p. 990.
van der Starre et al. (1980) J. Thorac. Cardiovasc. Surg. 79: 738-40.
Farber et al. (1992) Lancet 339: 119.
Bosner et al. (1991) Ann. Thorac. Surg. 52: 541-3.
Nurnberger et al. (1993) Ann. Hematol. 67: 17-21.

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