Use of c-Jun or c-Jun activating agents such as UV or c-Jun...

Details Use of c-Jun or c-Jun activating agents such as UV or c-Jun... Use of c-Jun or c-Jun activating agents such as UV or c-Jun...

2002-12-03

2008-12-02

Helms, Larry R. (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving luciferase

C435S373000

Reexamination Certificate

active

07459282

ABSTRACT:
The invention concerns the increased stabilization and activation of p73, a homologue of p53. Specifically, the inventors have determined that c-Jun, a component of the AP-1 family of transcription factors, is necessary for stabilization and activation of p73. Thus, there is provided a mechanism for initiating an apoptotic pathway involving c-June and p73 which can be exploited to combat cancers, particularly those lacking a functional p53.

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Rizzo et al. Postaglandins Leukotrienes and Essential Fatty Acids, vol. 60, No. 3, Mar. 1999, p. 187-198.
Zaika et al. (The J. of Biological Chemistry, vol. 276, pp. 11310-11316, Apr. 2001).
el-Deiry et al. (Curr. Opin. Oncol. vol. 9(1), pp. 79-87, 1997).
Zaika, A., et al., “Oncogenes Induce and Activate Endogenous p73 Protein,” The Journal of Biological Chemistry, 276:11310-11316 (2001).
Nabhan, J.F., et al., “ASchistosoma mansoniPad1 homologue stabilizes c-Jun,” Molecular & Biochemical Parasitology, 116:209-218, (2001).
Rizzo, M.T., et al., “Arachidonic acid induces mobilization of calcium stores and c-jun gene expression: evidence that intracellular calcium release is associated with c-jun activation,” Prostaglandins, Leukotrienes and Essential Fatty Acids, 60:187-198, (1999).
Hilberg, F., et al., “Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity,” Oncogene, 7:2371-2380, (1992).

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