Use of borate-polyol complexes in ophthalmic compositions

Details Use of borate-polyol complexes in ophthalmic compositions Use of borate-polyol complexes in ophthalmic compositions

1995-06-07

1998-09-22

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Contact lens treatment

Chemical sterilizing

134901, 422 28, 514839, A61L 216

Patent

active

058114661

ABSTRACT:
Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.

REFERENCES:
patent: 3975536 (1976-08-01), Stevenson et al.
patent: 4029817 (1977-06-01), Blanco et al.
patent: 4053628 (1977-10-01), Stevenson et al.
patent: 4410442 (1983-10-01), Lucas et al.
patent: 4525346 (1985-06-01), Stark
patent: 4559186 (1985-12-01), Lee
patent: 4581379 (1986-04-01), Nelson et al.
patent: 4710313 (1987-12-01), Miyajima et al.
patent: 4748189 (1988-05-01), Su et al.
patent: 4758595 (1988-07-01), Ogunbiyi et al.
patent: 4960799 (1990-10-01), Nagy
patent: 5011661 (1991-04-01), Schafer et al.
patent: 5032392 (1991-07-01), Varma
patent: 5141665 (1992-08-01), Sherman
patent: 5171526 (1992-12-01), Wong et al.
patent: 5188826 (1993-02-01), Chandrasekaran
patent: 5281277 (1994-01-01), Nakagawa et al.
patent: 5342620 (1994-08-01), Chowhan
Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, PA, p. 1445 (1980).
Rakow, P. L., Contact Lens Forum, (Jun., 1988), 41-46.
Okada, T. I., Chromatography, 403:27-33 (1987).
Sciarra, J. et al., J. Am. Pharm. Assoc., 49(2):115-117 (1960).
Morawetz, H., "Macromolecules in Solution", John Wiley & Sons, Inc., New York: 1974, pp. 402-404.
Gilman, H., et al. (eds), "Organic Chemistry", Vol. I, John Wiley & Sons, Inc., New York: 1950, pp. 432-433.
Gilman, H., et al. (eds.), "Organic Chemistry", vol. II, John Wiley & Sons, Inc., New York 1950, pp. 1549-1542, 1588, and 1589.
Gilman, H., et al. (eds.), "Organic Chemistry", vol. II, John Wiley & Sons, Inc., New York: 1950, pp. 1606-1610.
Chemical Abstracts, vol. 101 (1984): 86888j, Hentschell, et al., "Agent to preserve bacteriological specimens".
Chemical Abstracts, vol. 49 (1981): 135600g, Opus Chemical AB, "Borane complexes as bacterial preservaives".

Affiliated with

Also associated with

Rating

Use of borate-polyol complexes in ophthalmic compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of borate-polyol complexes in ophthalmic compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of borate-polyol complexes in ophthalmic compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1622261