Use of borate-polyol complexes in ophthalmic compositions

Details Use of borate-polyol complexes in ophthalmic compositions Use of borate-polyol complexes in ophthalmic compositions

1994-02-22

1996-04-09

Marquis, Melvyn I.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 7804, 424659, 424660, 514839, 514915, A61K 908, A61K 3322

Patent

active

055059538

ABSTRACT:
Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.

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