Use of bluetongue virus proteins as vaccine components

Details Use of bluetongue virus proteins as vaccine components Use of bluetongue virus proteins as vaccine components

1994-08-18

1998-11-10

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242151, 4353201, 514 44, 536 2372, A61K 3915, C12N 1546, C07H 2104

Patent

active

058339957

ABSTRACT:
A protective effect against bluetongue infection in susceptible mammals which is obtained by innoculating said mammals with a polypeptide comprising at least an antigenic portion of bluetongue virus structural protein VP2 in antigenic form produced by transforming a host with a recombinant expression vector having a DNA segment coding for said polypeptide.

REFERENCES:
Ellism, RW. "New Technologies for Making Vaccines" In: Vaccines, Plotkin & Mortimer Eds, W.B. Saunders Co. 1988 pp. 568-575.
Huismans, H. et al. 1983. In: Double-Stranded RNA Viruses. Compans & Bishop. Ed. pp. 165-172.
Buzofsky, J.A. et al. 1985 Science 229: 932-940.
Luckow, V.A. et al. 1988. Bio/Technology 6: 47-55.
Inumaru, S. et al. 1987. Virology 157: 472-479.
Purdy, M.A. et al. 1986 J. Gen. Virol. 67: 957-962.
Huismans et al. "The Biochemical and Immunological Characterization of Bluetongue Virus Outer Capsid Polypeptides" Double-Stranded RNA Viruses, 1983, pp. 165-172.

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