Use of bisphosphonates in endo-osteal bone surgery

Details Use of bisphosphonates in endo-osteal bone surgery Use of bisphosphonates in endo-osteal bone surgery

1993-03-24

1995-04-04

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514108, A61K 3166

Patent

active

054038294

ABSTRACT:
A method of enhancing the formation of bone tissue and/or eliminating late complications subsequent to bone surgery comprising administering an amount, which is safe and sufficient to promote the formation of bone tissue and/or eliminate late complications, of a compound of formula ##STR1## wherein X is H, OH, Cl, F or a methyl group and Y is Cl, OH, --(CH.sub.2).sub.2 --N(CH.sub.3)--(CH.sub.2).sub.4 --CH.sub.3, --(CH.sub.2).sub.n --CH.sub.3 or --(CH.sub.2).sub.n --NH.sub.2, where
n is zero or an integer of 1 to 8, --NHZ, where Z is pyridinyl or cycloheptyl, --SZ', where Z' is pyridinyl or chloro-substituted phenyl, or Y is a pyridinylsubstituted lower alkyl chain; or a non-toxic, pharmaceutically acceptable salt or ester thereof to a bone surgery patient.

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patent: 5227506 (1993-07-01), Saari et al.
patent: 5270365 (1993-12-01), Gertz et al.
Lehtinen, R. and A. Raunio, "The Effect of Chlodronate in the Rabbit Tibia Implanted with a Titanium Screw and an Osseointegration in Man". Abstract, Internationales Symposium, Oct. 6-9, 1991, Universitat Rostock Medizinische Fakultat Klinik Und Poliklinik Fur Mund-Kiefer-Gesichtschirurgie.

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