Use of biscistronic DNA constructs for identifying compounds...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C435S005000, C435S071100

Reexamination Certificate

active

10913269

ABSTRACT:
The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.

REFERENCES:
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patent: 6623961 (2003-09-01), Miles et al.
patent: 6667152 (2003-12-01), Miles et al.
patent: 6777179 (2004-08-01), Miles et al.
patent: 7045284 (2006-05-01), Miles et al.
patent: 2002/0160976 (2002-10-01), Miles et al.
Jubin et al. J. Infec. Diseas. 2000, vol. 181, pp. 331-334.

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