Use of biomolecular targets in the treatment and...

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...

Reexamination Certificate

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C435S004000, C435S007230

Reexamination Certificate

active

10328544

ABSTRACT:
The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor treatment therapies. The protein is also expressed in tissues from adenocarcinoma, non-melanoma, and renal carcinoma cells. Immunotherapeutic and immunoimaging agents that specifically bind to an identified brain tumor target protein are provided. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

REFERENCES:
patent: 1033404 (2000-09-01), None
patent: WO 00/20590 (2000-04-01), None
patent: WO 0020590 (2000-04-01), None
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Fredriksson et al., Novel Human G Protein-Coupled Receptors With Long N-Terminals Containing GPS Domains and SER/THR-Rich Regions, FEBS Letters, (2002), 531: 407-414.
Liu et al., GPR56, A Novel Secretin-Like Human G-Protein-Coupled Receptor Gene, Genomics, (1999), 55: 296-305.
Yano et al., Differential Expression of β-Catenin in Human Gliobastoma Multiforme and Normal Brain Tissue, Neurological Research, (2000), 22: 650-656.
Zendman et al., TM7XN1, A Novel Human EGF-TM7-Like CDNA, Detected With MRNA Differential Display Using Human Melonoma Cell Lines With Different Metastatic Potential, FEBS Letters, (1999), 292-298.

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