Use of biomarkers in saliva to evaluate the toxicity of agents a

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 71, 435 79, 435 793, 435 794, 435188, 436528, 436546, 436144, 436172, 436810, C12Q 100, G01N 33544

Patent

active

056862377

ABSTRACT:
Sensitive methods using a variety of biomarkers in oral saliva of humans and animals to detect measure, and quantify the presence of infectious and non-infectious agents and the functional status of living tissues in both (1) biomedical and (2) environmental applications. With in vivo biomedical applications, saliva samples are taken from human and animals and biomarker, such as enzyme or antibody levels, are measured. The extent of exposure to an agents is measured by the presence of specific chemical or biological constituents, by the degree of enzymes inhibition, or by the changes in the amount of the biochemicals in saliva. With in vitro environmental applications, enzymes or other biochemicals from animal or human saliva can be used to monitor the presence of toxic or reactive agents in tissue samples, urine, feces, milk, air, water, soil, or plants. The amount of toxicant in samples is estimated from a standard curve for that agent.

REFERENCES:
patent: 2359052 (1944-09-01), Scharer
patent: 3153616 (1964-10-01), Ito et al.
patent: 3763136 (1973-10-01), Huber et al.
patent: 4053363 (1977-10-01), Dorn
patent: 4066405 (1978-01-01), Henkin
patent: 4385125 (1983-05-01), Preti et al.
patent: 4594237 (1986-06-01), Ziegler
patent: 4619895 (1986-10-01), Cubicciotti
patent: 5332661 (1994-07-01), Adamczyk et al.
Alfonsky, D, 1961 Saliva and Its Relation to Oral Health. pp. 147-199. Paragon Press, Alabama.
Amdur, M. O. Doull, J., Klaassen, C.D., 1991. Casarett and Doull's Toxicology. The basic science of Poisons. Fourth Edition McGraw-Hill Inc.
Erdmann, E. 1980. Cardiac effects of vanadate. Basics Res. Cardiol. 75:411-412.
Friberg, L., Nordberg, G.F., and Vouk, V.B. 1986. Handbook on the Toxicology of Metals, vol. II, 2nd Edition, Elsevier.
Karlish, S.J.D. 1979. Vanadate inhibits (Na+ and K+) ATPase by blocking a conformational change of the unphosphorylated form. Nature 282:333-335.
Nechay, B.R. and Saunders, J.P. 1978. Inhibition by vanadium of sodium and postassium dependent adenosinetriphosphate derived from animal and human tissues. J. Environ. Path. Tox. 2:247-262.
Lopez, V., Stevens, T., and Lindquist, R.N. 1976. Vanadium ion inhibition of alkaline phosphatase-catalyzed phosphate ester hydrolysis. Arch. of Biochem. and Biophys. 175:31-38.
Phillips, T.D. 1982. Vanadium-induced inhibition of renal Na+, K+-ATPase in the chicken after chronic dietary exposure. J. Tox. Env. Health 9:651-661.
Tietz, N.W. 1986. Editor, Textbook of Clinical Chemistry. W.B. Sanders Company, Philadelphia.
Wang, T., Tsai, L., Solaro, R., Grassi de Gende, A., and Schwartz, A. 1979. Effects of Potassium on vanadate inhibition of sarcoplasmic reticulum Ca2+-ATPase from dog cardiac and rabbit skeletal muscle. Biochem. Biophys. Res. Commun. 91:356-361.
Borzelleca et al. Journal Enviromental Sciences and Health, "The Excretion of Pesticides in Saliva & its Value in Assessing Exposure," B 15(6), 843-866 (1980).
Nigg et al., Chemosphere, "Quantification of Human Exposure to Ethion using Saliva," vol. 26, No. 5, 897-906 (1993).
Eldefrawi et al., Biomarkers of Human Exposure to Pesticides, "Regulation of Muscarine Receptors as Biomarkers of Exposure to Insecticides," ACS 542, pp. 51-63, 1994.
Nauman et al., Biomarkers of Human Exposure to Pesticides, "Biomonitoring for Pesticide Exposure." ACS 542 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of biomarkers in saliva to evaluate the toxicity of agents a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of biomarkers in saliva to evaluate the toxicity of agents a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of biomarkers in saliva to evaluate the toxicity of agents a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1227761

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.