Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-05-17
2005-05-17
Tsang, Cecilia J. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C552S617000
Reexamination Certificate
active
06894038
ABSTRACT:
The invention relates to the use of esters of estriol, for example, an estriol 3,17-dipropionate or an estriol 3,17-dihexanoate, for the treatment of autoimmune diseases, such as multiple sclerosis (MS).
REFERENCES:
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patent: WO 0185154 (2001-11-01), None
Kim Sookhyun et al.: “Mechanisms in the shift toward TH2 during pregnancy: A role for estriol. Treatment of TH1 mediated disease.” FASEB Journal, vol. 12, No. 4 Mar. 17, 1998 p. A616 XP001108910.
Kim S et al: “Estriol Ameliorates Autoimmune Demyelinating Disease Implications for Multiple Sclerosis” Neurology, Lippincott Williams & Wilkins, Philadelphia, US, vol. 52, No. 1, Apr. 12, 1999 pp. 1230-1238, XP001026663.
Zang Ying C Q et al.: “Regulatory effects of estriol on T cell migration and cytokine profile: Inhibition of transcription factor NF-kappaB.” Journal of Neuroimmunology, vol. 124, No. 1-2, Mar. 2002 pp. 106-114, XP002213672.
Heithecker, R. et al.: “Plasma estriol levels after intramuscular injection of estriol and two of its esters” Horm. Res. (1992), 35(6), 234-8, XP008008290.
Beier Sybille
Dahlke Frank
Elger Walter
Von Keyserlingk Harald
Hermenau Ronald S.
Oh Taylor Victor
Schering Aktiengesellschaft
Tsang Cecilia J.
Washtien Wendy L.
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