Use of binding protein with IGF-I as an anabolic growth promotin

Details Use of binding protein with IGF-I as an anabolic growth promotin Use of binding protein with IGF-I as an anabolic growth promotin

1991-02-12

1993-02-16

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 530303, 530324, A61K 3726, C07K 500

Patent

active

051871513

ABSTRACT:
A method is disclosed for producing an anabolic state in a mammal by co-administration by subcutaneous injection of a combination of effective amounts of IGF-I and an IGF binding protein in a defined molar ratio in the absence of growth hormone so as to produce a greater anabolic response in the mammal than that achieved using IGF-I alone in an amount equal to that used for IGF-I in the combination. Preferably, the IGF-I is native-sequence, mature human IGF-I, the binding protein is IGFBP-3, and the mammal is human or a non-human animal of economic importance such as a cow or pig.

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