Use of bile acid derivatives conjugated with metal ion...

Details Use of bile acid derivatives conjugated with metal ion... Use of bile acid derivatives conjugated with metal ion...

2006-10-31

2006-10-31

Jones, Dameron L. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S009100, C424S009200, C424S009300, C424S001450, C424S001650

Reexamination Certificate

active

07128895

ABSTRACT:
The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed.

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Betebenner et al; “Hepatobiliary Delivery of Polyaminopolycarboxylate Chelates: Synthesis and Characterization of a Cholic Acid Conjugate of EDTA and Biodistribution and Imaging Studies With its Indium-111 Chelae”; Bioconjugate Chemistry, American Chemical Society, Washington, US, vol. 2, No. 2, 1991, pp. 117-123, XP002137988.
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