Use of biguanide derivatives for making a medicine having a...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S634000, C514S969000

Reexamination Certificate

active

10297003

ABSTRACT:
The present invention relates to the use of biguanide derivatives of general formula I below:in which:the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C1–C7, alkyl group, a cycloalkyl group, a heterocycle, a C2–C7alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group,or R1 and R2, taken together, represent a C2–C7alkylene which may contain one or more hetero atoms,and the group R3 represents a primary, secondary or tertiary amine,or pharmaceutically acceptable salts thereof, to manufacture a medicinal product with cicatrizing action, the said medicinal product being in a pharmaceutical form for topical use.

REFERENCES:
patent: 2961377 (1960-11-01), Shapiro
patent: 3098008 (1963-07-01), Shapiro et al.
patent: 3174901 (1965-03-01), Sterne et al.
patent: 3468898 (1969-09-01), Cutler
patent: 3808224 (1974-04-01), Didier
patent: 3852353 (1974-12-01), Heaphy
patent: 3929999 (1975-12-01), Heaphy
patent: 3996232 (1976-12-01), Diamond et al.
patent: 4028402 (1977-06-01), Fischer et al.
patent: 4163800 (1979-08-01), Wickett et al.
patent: 4814334 (1989-03-01), Salkin
patent: 4835184 (1989-05-01), Hugelin et al.
patent: 5567716 (1996-10-01), Della Valle et al.
patent: 5668084 (1997-09-01), Unhoch
patent: 5741926 (1998-04-01), Bierer et al.
patent: 5747527 (1998-05-01), Inman et al.
patent: 5770582 (1998-06-01), Bamat et al.
patent: 5811078 (1998-09-01), Maycock et al.
patent: 5827898 (1998-10-01), Khandwala et al.
patent: 5837255 (1998-11-01), Inman et al.
patent: 5872145 (1999-02-01), Plachetka
patent: 6031004 (2000-02-01), Timmins et al.
patent: 6117437 (2000-09-01), Roreger
patent: 6228863 (2001-05-01), Palermo et al.
patent: 6248363 (2001-06-01), Patel et al.
patent: 6251428 (2001-06-01), Yoo
patent: 6414126 (2002-07-01), Ellsworth et al.
patent: 6515117 (2003-02-01), Ellsworth et al.
patent: 6610746 (2003-08-01), Fryburg et al.
patent: 2002/0143039 (2002-10-01), Krajcik et al.
patent: 1197643 (1998-11-01), None
patent: 0297828 (1988-06-01), None
patent: 0283369 (1988-09-01), None
patent: 0477143 (1992-03-01), None
patent: 0535446 (1993-04-01), None
patent: 0535446 (1993-04-01), None
patent: 0643044 (1994-09-01), None
patent: 0852148 (1998-07-01), None
patent: 0852148 (1998-07-01), None
patent: 2.213.778 (1974-08-01), None
patent: 2320735 (1977-03-01), None
patent: 852584 (1957-05-01), None
patent: 21355834 (1984-02-01), None
patent: 10-265391 (1998-10-01), None
patent: 10265391 (1998-10-01), None
patent: 1560212 (1990-04-01), None
patent: WO 00/33829 (1998-12-01), None
patent: WO 01/21159 (2001-03-01), None
patent: WO2001062237 (2001-08-01), None
Merck Index(12th edition, 1996), 6001 Metformin, see p. 1014.
U.S. Appl. No. 60/158,773, filed Oct. 23, 1999(Ellsworth et al), pp. 1-82, see especially pp. 37-38(particularly relevant).
Hyperdictionary(medical), www.hyperdictionary.com, definition of “WOUND” based on 1913 webster dictionary.
Cicatrization definition form On-line Medical dictionary, Mar. 2000.
Barletta et al., Action of chlorhexidine gluconated on cicatrization in simple . . . , (abstract only), Revista de al Ascociacion Odontologica Argentina, Oct.-Nov. 1978 vol. 66, Nov. 4, pp. 207-212.
Nicolaus B.J.R., “Symbiotic Approach to Drug Design”, Decision Making in Drug Research, 1983, pp. 173-185.
Diabetes & Metabolism “Membrane Physiology as a Basis For the Cellular Effects of Metformin in Insulin Resistance and Diabetes”, Wiensperger N.F., 1999, pp. 110-127.
Diabetic Medicine, “The Influence of Hypoglycaemic Agents on the Growth and Metabolism of Human Endothelial Cells”, R. G. Petty et al., 1992, 8 pages.
Weidner, F., Dermatologie“Ummunologic and inflammatory vascular lesions; clinical features and treatment in dermatology; Immunologische und entzundiiche Gefaβschaden: Klinik und therapie in der Dermatologie”, THERAPIEWOCHE 29/116 2769-2779 (1979).
Cavaleri, F. et al., Osservazioni sull'impiego degli ipoglicemizzanti orali in dermopazienti diabetici, con particolare riguardo all'associazione glibenclamide-fenformina (Surguan), Terapia Dermatologica, Minerva Dermatologica, 112, pp. 255-266, 1977.
Shornick, J. et al., “Idiopathic atrophie blanche”, Journal of the American Academy of Dermatology, 8/6 pp. 792-798, 1983.
Mihailova, Ev et al., “Good healing effects of di-methyl sulphoxide and insulin on necrobiosis liquida diabeticorum in type-1 diabetes”, European Journal of Enducinology, vol. 130, n. suppl 2, p. 202, 1992.
Cunliffe, W.J., “Dowling oration 1975. Fibrinolysis and Vasculitis”, Clinical and Experimental Dermatology, pp. 1-16, Mar. 1976.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of biguanide derivatives for making a medicine having a... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of biguanide derivatives for making a medicine having a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of biguanide derivatives for making a medicine having a... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3724063

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.