Use of bicyclic imidazole compounds for the treatment of hyperal

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514210, 514214, 5142278, 5142358, 514255, 514393, 514413, A61K 3141

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active

050575210

ABSTRACT:
The invention relates to specific bicyclic imidazole compounds such as 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine, or pharmaceutically acceptable non-toxic salts thereof, for the treatment of hyperaldosteronism, and to a method of treating hyperaldosteronism using such compounds, as well as to the use of said compounds for the preparation of pharmaceutical compositions for the treatment of hyperaldosteronism.

REFERENCES:
patent: 4588732 (1986-05-01), Browne
patent: 4617307 (1986-10-01), Browne
patent: 4728645 (1988-03-01), Browne
patent: 4889861 (1989-12-01), Browne
Chemical Abstracts; vol. III (1989), #187280s; Lamberts et al.
Clin. Research 37, No. 2,535A (1989).
Oral presentation of Dr. J. R. Hanagan, 10/6/88, Pretoria, South Africa.
Journal of Clinical Endocrinology and Metabolism, 68, No. 1, 99-106 (1989).
Dose-Related Endocrine Study of Aramatase Inhibitor.
Abstract of oral presentation of Dr. Santen at the 70th annual meeting of the Endocrine Society.
J. Endocrinol., 119 (Suppl.) 1988, Abstract 123.

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