Use of betaine as a hepatic generator of S-adenosylmethionine an

Details Use of betaine as a hepatic generator of S-adenosylmethionine an Use of betaine as a hepatic generator of S-adenosylmethionine an

1994-04-11

1995-06-27

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562573, A61K 31195

Patent

active

054280630

ABSTRACT:
This invention encompasses pharmaceutical compositions in the dietary supplement for treating or preventing fatty infiltration, the first stage of cirrhosis of the liver comprising and administering of not less than 1500 mg of betaine per kg of body weight per day. Dietary supplementation of betaine was shown to completely protect against liver fatty infiltration in rats exposed to prolonged ethanol intake as well as carbon tetrachloride. Hepatic levels of SAM were also elevated, which suggests the mechanism for the protection of the liver.

REFERENCES:
patent: 3242048 (1966-03-01), Straub et al.
Barak, 1993, Dietary Betaine Promotes Generation of Hepatic S-Adenosylmethionine and Protects the Liver from Ethanol-Induced Fatty Infiltration, Alcoholism: Clinical and Experimental Research, vol. 17; No. 3.
Barak, 1987, Effects of Prolonged Ethanol Feeding on Methionine Metabolism in Rat Liter, Biochem Cell Biol. vol. 65.
Beckenhauer, 1992, Effect of Betaine on Hepatic S-Adenosylmethionine (SAM) in Control and Alcohol-Fed Rats, Alcoholism, vol. 16, No. 3.
Beckenhauer, 1993, Relationship of Administered Dietary Levels of Betaine to Hepatic S-Adenosylmethionine and Triglyceride, Hepatology, vol. 18, No. 4, Pt. 2.
CA: 71:80801r-Logeais (1969).

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