Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1988-06-06
1990-03-13
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31135
Patent
active
049083872
ABSTRACT:
A method of treating inflammation and joint deterioration in mammals which comprises administering a therapeutically effective amount of a selective beta.sub.2 adrenergic receptor antagonist. The method is particularly useful for the treatment of rheumatoid arthritis in humans.
REFERENCES:
Chem. Abst., vol. 102 (1985)-197713p.
Vyden et al., "The Effect of Propranolol on Peripheral Hemodynamics in Rheumatoid Arthritis," Arthritis and Rheumatism (1971) 14:420.
Levine et al., "Contribution of Sensory Afferents and Sympathetic Efferents to Joint Injury in Experimental Arthritis," J. Neurosci. (1986) 6:3423-3429.
Levine et al., "Clinical Response to Regional Intravenous Guanethidine in Patients with Rheumatoid Arthritis," J. Rheumatol. (1986) 13:1040-1043.
Kaplan et al., "Propranolol and the Treatment of Rheumatoid Arthritis," Arthritis and Rheumatism (1980) 23:253-255.
Levine et al., "Hypothesis: The Nervous System May Contribute to the Pathophysiology of Rheumatoid Arthritis," J. Rheumatol. (1985) 12:406-411.
"A Comprehensive Report on the Pharmacology and Toxicology of Butoxamine (B.W. 64-9)," Burroughs Wellcome & Co. (1965).
"A Supplementary Report on the Pharmacology and Toxicology of Butoxamine (B.W. 64-9)," Burroughs Wellcome & Co. (1966).
Basebaum Allan I.
Levine Jon D.
Friedman Stanley J.
The Regents of the University of California
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