Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1996-08-02
1998-12-29
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514351, 514584, A01N 4340, A01N 4728
Patent
active
058542884
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP94/03728 filed Nov. 11, 1994.
The invention relates to a method of controlling house dust mites by applying certain benzoylureas as acaricidal active substance.
Numerous kinds of mites live on the earth. For example, mites of Panonychus citri, Tetranychus urticae, etc. that are parasitic on plants cause serious damage to crops. Agricultural miticides for mites of these kinds have been developed from the past, and novel and useful compounds have been found one after another in these days.
On the other hand, recent variations in living surroundings result in the increase in mites living in indoor dust (hereinafter referred to as "house dust mites"), such as those of Tyrophagus, Dermatophagoides, Cheyletidae, etc., which are problematic in that they are not only unpleasant but also cause allergic asthma and rash.
In particular large numbers of house dust mites in dwellings are a problem. Their excretions result in dust particles which contain allergenic constituents and can therefore trigger allergic diseases in humans (D. Stollewerk, Allergologie 11 (9), 371-90 (1988)).
The control of house dust mites requires acaricidal active substances which have a high degree of effectiveness, specifically in the relevant species such as Dermatophagoides farinae, Dermatophagoides pteronyssinus, Euroglyphus maynei, Tyrophagus putrescentiae, Acarus siro, Glycophagus domesticus, lepidoglyphus destructur, Chelacaropsis moorei, Cheyletus eruditus, Cheyletus fortis, Cheletomorpha lepidopterorum and Hemicheyletia bakeri, have a sufficiently good long-term action and can be classified as acceptable with regard to their toxicity to warm-blooded species.
The majority of the commercially available acaricides and insecticides do not have the biological and toxicological properties which are desirable for controlling house dust mites.
It is known that organic phosphorus insecticides such as fenitrothion and diazinon as well as pyrethroid insecticides such as phenothrin and permethrin are effective against such house dust mites living in houses. However, since the miticidal components in these insecticides are all contact poisons, the contact between the insecticides and mites is indispensable. Therefore, when the insecticides are desired to be applied to the place where mites will live, such as the substrate of a carpet, a large amount of it must be applied to its whole surface. However, such is extremely difficult and is not practical, since its safety for human beings, especially infants is not sure. House dust mites are generally weak to heat and will die almost completely at 70.degree. C. for several minutes. In addition, they cannot live under dry conditions. For these reasons, a physical method for treating tatami mats or carpets with high frequency under heat or for drying bedclothes so as to kill mites living therein is effective. However, as being not simple, the method is troublesome. Given the situations, a more suitable method for satisfactorily killing mites is desired.
Benzoylurea compounds are known as inhibitors for the biosynthesis of chitin in insects and mites and have been disclosed in Japanese Patent Laid-Open Application (hereinafter referred to as "JP-A") No. HEI-2-270 to have a high insecticidal and acaridical efficacies against various harmful insects such as, for example, mosquitoes, flies and cockroaches as well as mites parasitic on plants.
Benzoylurea compounds such as diflubenzuron and teflubenzuron which have heretofore been developed have high insecticidal and acaricidal activities against sanitary insects such as mosquitoes, flies and cockroaches and mites of Acarina parasitic on plants but are almost ineffective against house dust mites. The reason is considered because of the essential morphological difference between them in that mites of Acarina parasitic on plants belong to the phylum Stigmata while house dust mites belong to the phylum Astigmata.
Furthermore, most insecticidal benzoylphenylureas are well known to be not active against house dust mites.
Surprisi
REFERENCES:
patent: 4609676 (1986-09-01), Brouwer et al.
patent: 4666942 (1987-05-01), Anderson
patent: 4954529 (1990-09-01), Koch et al.
A.S. Downing et al. Chemical Abstracts, vol. 114, No. 1, Jan. 7, 1991, abstract No. 2243.
A.C. Grosscurt. Pesticide Science, vol. 9, 1978, pp. 373-386.
A.C. Grosscurt. Pesticide Science, vol. 22, No. 1, 1988, pp. 51-59.
Katsuda Yoshio
Mildenberger Hilmar
Schnatterer Stefan
Schubert Hans-Herbert
Stark Herbert
Hoechst Schering AgrEvo GmbH
Robinson Allen J.
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