Use of Bcl inhibitors for the prevention of...

Details Use of Bcl inhibitors for the prevention of... Use of Bcl inhibitors for the prevention of...

2007-08-31

2010-12-28

Wax, Robert A (Department: 1615)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C424S423000

Reexamination Certificate

active

07857804

ABSTRACT:
The present invention relates to new use of inhibitors of bcl-2/bcl-Xl family of anti-apoptotic compounds for the treatment of post-angioplasty restenosis and in-stent restenosis. Small molecules of Bcl inhibitors are incorporated into a stent, typically by a fine polymeric coating over the metal, which would be placed during angioplasty of occluded blood vessels, to act on fibroproliferative in-growth. Hollow organs such as urethras, Fallopian tubes and vascular access grafts could be treated in a similar manner to prevent their closure due to fibrosis. Other iatrogenic fibrosis such as adhesions after surgery could also be blocked by this therapy.

REFERENCES:
patent: 5776905 (1998-07-01), Gibbons
patent: 2002/0137732 (2002-09-01), Wang
patent: 2003/0199489 (2003-10-01), Wang
patent: 2005/0239873 (2005-10-01), Hockenbery
patent: 2006/0111288 (2006-05-01), Cotter
patent: 2006/0178435 (2006-08-01), Wang
patent: 2006/0241067 (2006-10-01), Varner
patent: 2006/0247305 (2006-11-01), Wang
patent: 2006/0247318 (2006-11-01), Song
patent: WO02097053 (2002-12-01), None

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