Use of azetidinone compounds

Details Use of azetidinone compounds Use of azetidinone compounds

2006-12-05

2006-12-05

Paras, Jr., Peter (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100, C435S007200, C435S007210, C514S023000, C514S210020

Reexamination Certificate

active

07144696

ABSTRACT:
The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.

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