Use of azetidinone compounds

Details Use of azetidinone compounds Use of azetidinone compounds

2005-08-23

2005-08-23

Celsa, Bennett (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100, C435S007200, C435S007210, C514S023000, C514S210020

Reexamination Certificate

active

06933107

ABSTRACT:
The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.

REFERENCES:
patent: 4144232 (1979-03-01), Koppel et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4443372 (1984-04-01), Luo et al.
patent: 4479900 (1984-10-01), Luo et al.
patent: 4500456 (1985-02-01), Spitzer et al.
patent: 4576749 (1986-03-01), Zahler et al.
patent: 4576753 (1986-03-01), Kamiya et al.
patent: 4595532 (1986-06-01), Miller
patent: 4620867 (1986-11-01), Luo
patent: 4633017 (1986-12-01), Mueller et al.
patent: 4675399 (1987-06-01), Miller
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4784734 (1988-11-01), Torri et al.
patent: 4794108 (1988-12-01), Kishimoto et al.
patent: 4803266 (1989-02-01), Kawashima et al.
patent: 4834846 (1989-05-01), Abramson et al.
patent: 4876365 (1989-10-01), Kirkup et al.
patent: 4879069 (1989-11-01), Morand et al.
patent: 4983597 (1991-01-01), Yang et al.
patent: 5030628 (1991-07-01), Joyeau et al.
patent: 5099034 (1992-03-01), Yoshida et al.
patent: 5120729 (1992-06-01), Chabala et al.
patent: 5229381 (1993-07-01), Doherty et al.
patent: 5229510 (1993-07-01), Knight et al.
patent: 5306817 (1994-04-01), Thiruvengadam et al.
patent: 5348953 (1994-09-01), Doherty et al.
patent: 5350868 (1994-09-01), Yoshida et al.
patent: 5412092 (1995-05-01), Rey et al.
patent: 5550229 (1996-08-01), Iwasaki et al.
patent: 5661145 (1997-08-01), Davis
patent: 5688785 (1997-11-01), Vaccaro
patent: 5688787 (1997-11-01), Burnette et al.
patent: 5688990 (1997-11-01), Shankar
patent: 5728827 (1998-03-01), Thiruvengadam et al.
patent: 5817806 (1998-10-01), Rossi et al.
patent: 5847115 (1998-12-01), Iwasaki et al.
patent: 5925333 (1999-07-01), Krieger et al.
patent: 6031094 (2000-02-01), Tsien et al.
patent: 2046823 (1972-03-01), None
patent: 199630 (1986-10-01), None
patent: 0 219 876 (1987-04-01), None
patent: 264231 (1988-04-01), None
patent: 0 267 878 (1988-05-01), None
patent: 0 323 807 (1989-07-01), None
patent: 0 333 268 (1989-09-01), None
patent: 337549 (1989-10-01), None
patent: 0 365 364 (1990-04-01), None
patent: 0 390 112 (1990-10-01), None
patent: 0 415 487 (1991-03-01), None
patent: 0 462 667 (1991-12-01), None
patent: 0 481 671 (1992-04-01), None
patent: 0 524 595 (1993-01-01), None
patent: 2 203 149 (1988-10-01), None
patent: WO 87/04429 (1987-07-01), None
patent: 93/02048 (1993-02-01), None
patent: 94/17038 (1994-08-01), None
patent: 95/01356 (1995-01-01), None
patent: 97/18304 (1997-05-01), None
Ram et al., 1990,Indian J. Chem., Sect B, 29B 12:1134-7.
Hoekman et al., 1982,J. Agric. Food Chem., 30:920-924.
Durst et al., 1972,Can. J. Chem., 50:3196-3201.
Otto et al., 1983,Liebigs Ann. Chem., pp. 1152-1161.
Panfil, et al., 1986,Heterocycles24:6 pp. 1609-1617.
Schnitzer-Polokoff et al., 1991,Comp. Biochem. Physiol., 99A: pp. 665-670.
Witzum,Circulation, 1989, 80:5 pp. 1101-1114.
Illingworth,Drugs1988, 36:Supp.3 pp. 63-71.
Allain et al.,Clin. Chem., 1974, 20:470-475.
Horie et al.,Atherosclerosis, 1991, 88:183-192.
Baxter et al.,J. Biological Chem., 1992, 276:17 pp. 11705-11708.
Salisbury,Atherosclerosis1995, 115:45-63.
Burrier,Biochemical Pharmacology, 1994, 47:9 pp. 1545-1551.
Harwood, H. James, Jr. et al.,Journal of Lipid Research, 1993, 34:377-395.
Current Drugs:Anti-Atherosclerotic Agents—Summary Factfile, May 1992.
Georg, Gunda I. et al.,Tetrahedron Letters, 1985, 26:33 pp. 3903-3906.
Hart, David J., et al.,Tetrahedron Letters, 1985, 26:45 pp. 5493-5496.
Simova, E., The American Chemical Society, Chemical Abstracts, 1977, 86:15 1-556.
Otto et al., The American Chemical Society, Chemical Abstracts, 1983, 99:19 1-661.
Nobuki, O. et al., The American Chemical Society, Chemical Abstract, 1977, 106:17 1-727.
Mayrhofer, Roswitha, et al., 1980,Communications, pp. 247-248.
Burrier, et al., 1994,The Journal of Pharmacology and Experimental Therapeutics, 272:1 pp. 156-163.
Clader, John W., et al., 1995,Journal of Medicinal Chemistry, 38:10 pp. 1600-1607.
Sybertz, Edmunh J., et al., 1995,Atherosclerosis, pp. 311-315.
Olsson, R.A., Physlological Reviews, 70:3 Jul. 1990, pp. 761-845.
Daly, John W.,Journal of Medicinal Chemistry, 25:3 Mar. 1982, pp. 197-207.
Belardinelli, Luiz, et al., 1989, Progress in Cardiovascular Diseases, 32:1 pp. 73-97.
Jacobson, Kenneth A., et al., 1992,Journal of Medicinal Chemistry, 35:3 pp. 4143-4149.
Stone, Trevor W., “Purine Receptors and their Pharmacological Roles,”Advances in Drug Research, 18:291-429.
Conti, A. et al., “Role of 5-HT2 Receptors in Serotonin-Induced Contraction in the Human Mammary Artery,”European Journal of Pharmacology, 1990, 176:207-212.
Collis, M.G., “Evidence for an A1-adenosine receptor in the guinea-pig atrium”Br. J. Pharmac, 78:207-212.
Born, G.V.R. et al., “The Aggregation of Blood Platelets,”J. Physiol., 1963, 168:178-195.
Monopoli, A. et al., “Antihypertensive Activity of a New ACE-Inhibitor, SCH 33844, during Repeated Administration in Spontaneously Hypertensive Rats,” 1987,Arch. Int. Pharmacodyn286:246-254.
Cristalli, Gloria et al.,J. Med. Chem., 1992, 35:2363-2368.
Bruns, Robert F., et al., 1980,Proc. Natl. Acad. Sci.77:9 pp. 5547-5551.
Jarvis, Michael F., et al.,The Journal of Pharmacology and Experimental Therapeutics251:3 pp. 888-893.
Bruns, Robert F., et al.,Molecular Pharmacology, 29:331-346.
Mukherjee, S. et al.,Biophysical Journal, 75:1915 (XP000938151) ISSN: 0006-3495 abstract (Oct. 1998).
Vaccaro, W. D. et al.,Bioorganic&Medicinal Chemistry Letters, 8:313 (XP004136870) ISSN: 0960-894X (Feb. 3, 1998).
Acton et al.,The Journal of Biological Chemistry, 269:33 pp 21003-21009 (Aug. 19, 1994).
Schroeder, F. et al., “Cholesterol Domains in Biological Membranes”,Mol. Membr. Biol., 12:113 (XP000938276) abstract (1995).
Hesk, D. et al., “Synthesis of3H and14C Labelled Sch 48461”,Journal of Labelled Compounds and Radiopharmaceuticals, 38:1039 (XP000938019) ISSN: 0362-4803 (1996).

Affiliated with

Also associated with

Rating

Use of azetidinone compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of azetidinone compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of azetidinone compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3497576