Use of azapaullones for preventing and treating pancreatic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S521000

Reexamination Certificate

active

07968535

ABSTRACT:
This invention relates to the use of azapaullones, particularly in combination with immunomodulating agents, in the prevention, and/or treatment of pancreatic autoimmune disorders, e.g. type I diabetes or LADA and neurodegenerative disorders.

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patent: 2005/0171094 (2005-08-01), Kataoka et al.
patent: 1477490 (2004-11-01), None
patent: WO 02/086107 (2002-10-01), None
patent: WO 03/011843 (2003-02-01), None
Kunick et al. (Bioorganic & Medicinal Chemistry Letters (2004), 14(2), 413-416).
Cohen Philip et al: “GSK3 inhibitors: development and therapeutic potential,” Nature Reviews. Drug Discovery. Jun. 2004, vol. 3, No. 6, Jun. 2004, pp. 479-487, XP002357670 ISSN: 1474-1776.
Martinez A et al: “Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation” Medicinal Research Reviews 2002 United States, vol. 22, No. 4, 2002, pp. 373-384, XP009058328 ISSN: 0198-6325.

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