Use of aspirin for the manufacture of a medicament for implantin

Details Use of aspirin for the manufacture of a medicament for implantin Use of aspirin for the manufacture of a medicament for implantin

1997-12-05

2000-08-08

Moezie, Minna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

A61K 3160

Patent

active

061002496

ABSTRACT:
The invention provides the use of a cycloaygenase inhibitor such as the non-steroidal anti-inflammatory agent aspirin in the manufacture of a medicament to enhance perfusion of blood through the mammalian, preferably human, uterus. The enhanced perfusion aids implantation in natural or assisted methods of conception

REFERENCES:
patent: 5760024 (1998-06-01), Macnamee
Takashima, M., et al., "A Trial of Low-Dose Aspirin Therapy in High-Risk Pregnancy", Database Medline, U.S. National Liberty of Medicine (NLM), Bethesda, MD. (Abstract), 1980.
Zeev Weiner, et al., "Umbilical and Uterine Artery Flow Velocity Waveforms in Pregnant Women With Systemic Lupus Erthematosus Treated With Aspirin and Glucocorticosteroids", Am. J. Repr. Immunol., vol. 28, No. 3-4, 1992, pp. 168-171.
C.M.G. Thomas, et al., "Effect of Prostaglandin F2 Alpha, Indomethacin and Estradiol on Ovum Trasport and Pregnancy in the Golden Hamster", Biology of Reproduction, vol. 23, 1980, pp. 687-698.
R.K. Goswamy, et al., "Decreased Uterine Prefusion--A Cause of Infertility", Human Reproduction, vol. 3, No. 8, 1988, pp. 955-959.
K. Wollenhaupt, et al., "Untersuchungen zur Beeinflussung des Implantationsgeschehens bei Ratten und Sauen durch perorale Verabreichung von Prostaglandinsynthetasehemmern", Arch. Exper. Vet Med., vol. 35, No. 3, 1981, pp. 465-470.
Kautiainen M., et al., "Effects of Drugs on Perfusion and Intrauterine Pressure in Isolated Human Uterus", Database Embase, Elsevier Science Publishers, Amsterdam, NL., 1979.

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