Use of arsenite to reversibly block steroid binding to glucocort

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 721, 435 77, 435962, 435975, 436503, 436504, 436817, 436825, G01N 33574

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active

051734052

ABSTRACT:
The present invention is directed to a method for selectively blocking or inactivating glucocorticoid receptors by administering a glucocorticoid receptor blocking effective amount of arsenite or methyl methanethiolsulfonate (MMTS) in a sample. Thus, arsenite and MMTS constitute new, simple, reversible, and inexpensive reagents for assaying glucocorticoid receptors in the presence of other receptors and for eliminating the complications of assaying other receptors in the presence of glucocorticoid receptors.

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International Search Report.

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