Use of arginine as an immunostimulator

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514573, 514885, A61K 31195, A61K 3119

Patent

active

055763510

ABSTRACT:
The present invention relates to the treatment of an impaired human immune response or to reduction of the severity of degradation of the human immune response by the administration of arginine or ornithine, or a functional analog of arginine or ornithine, or mixtures thereof, to humans suffering from an impaired immune response or at risk of suffering an impaired immune response. Such treatment is provided by enterally administering compositions supplemented with arginine or ornithine, or functional analogs of arginine or ornithine, or parenterally administering amino acid solutions supplemented with arginine or ornithine, or functional analogs of arginine or ornithine, to the patient.

REFERENCES:
patent: 3950529 (1976-04-01), Fischer et al.
patent: 4340592 (1982-07-01), Adibi
patent: 4385068 (1983-05-01), Kendall et al.
patent: 4439448 (1984-03-01), Munakata et al.
patent: 4491589 (1985-01-01), Dell et al.
patent: 4752618 (1988-06-01), Mascioli et al.
patent: 4758553 (1988-07-01), Ogoshi
patent: 4832465 (1989-05-01), Ghadimi
patent: 5053387 (1991-10-01), Alexander
patent: 5231085 (1993-04-01), Alexander et al.
Barbul, "Arginine: Biochemistry, Physiology, and Therapeutic Implications," JPEN, 10, 227-238 (1986).
Madden et al, "Prolonged Thymotropic Effect After One Week of Oral Arginine (ARG) Supplementation," Abstract. Fed. Proc., 46, 558, #1586 (1987).
Levenson et al, "Citrulline Replaces Arginine as a Dietary Essential in Rats; Ornithine Does Not," Fed. Proc. 39, 726, #2421 (1980).
Critselis et al, "Arginine Inhibits a Viral Tumor," Fed. Proc., 36, 1099, Abstract #4380 (1977).
Barbul et al, "Thymotropic Actions of Arginine (ARG), Ornithine (ORN) and Growth Hormone (GH)" Fed. Proc. , 37, 264, Abstract #282 (1978).
Rettura et al, "Ornithine Inhibits Two Murine Tumors," Fed. Proc., 37, 358, Abstract #779 (1978).
Barbul et al, "Thymus-Arginine Interactions in Wound Healing (WH)," JPEN, 5, 567, Abstract #56 (1981).
Madden et al, "Prolonged Thymotropic Effect After One Week of Oral Arginine (ARG) Supplementation," (FASEB Abstract Form) (1987).
Barbul et al, "Arginine Increases The Number of T Lymphocytes in Nude Mice," JPEN , 13, 7S, Abstract #14 (1989).
Rettura et al, "Supplemental Vitamin A (VA) or L-Arginine (AR) Inhibit Regrowth of Transplanted C3HBA Tumors," 18th Mid-Atlantic Regional Meeting of the American Chemical Society, Apr., 1984, Newark, New Jersey.
Seifter et al, "Anabolic Effects of L-Arginine and L-Ornithine," Biochem 23, 3382 (1984).
Rettura et al, "Putrescine (PU) Does Not Have Thymotropic Properties of Ornithine (ORN) and Arginine (ARG)," J.Am.Col.Nutr., 1, 423, (1982).
Rettura et al, "Citrulline Does Not Share the Thymotropic Properties of Arginine and Ornithine," Fed. Proc, 38, 289, #343, 1980.
Seifter, "Supplemental Arginine Increases Survival in Mice Undergoing Local Tumor Excision," JPEN, 4, 589, Abstract #38 (1980).
Barbul et al, "Thymotropic Actions of Arginine (ARG) and Metabolites," J.Am.Col.Nut., 1, 115, Abstract #44 (1982).
Rettura et al, "Supplemental Arginine (ARG) and Ornithine (ORN) Promote Allograft Rejection," AGFD, Abstract #11 (1982).
Madden et al, "Stimulation of T Cell Immunity by Arginine Enhances Survival in Peritonitis," J.Surg.Res., 44, 658-663 (1988).
Barbul et al, "Optimal Levels of Arginine in Maintenance Intravenous Hyperalimentation," JPEN, 8, 281-284 (1984).
Barbul et al, "High Arginine Levels in Intravenous Hyperalimentation Abrogate Post-traumatic Immune Suppression," J.Surg.Res., 36, 620-624 (1984).
Barbul et al, "Wound healing and Thymotropic Effects of Arginine: A Pituitary Mechanism of Action," A.J.Clin.Nutr., 37, 786-794 (1983).
Barbul et al, "Nitrogen-Sparing and Immune Mechanisms of Arginine: Differential Dose-Dependent Responses During Postinjury Intravenous Hyperalimentation," Curr.Surg., 40, 114-116 (1983).
Barbul et al, "Immunostimulatory Action of Arginine in Humans," Surg.Forum.31, 82-84 (1980).
Barbul et al, "Thymic Stimulatory Actions of Arginine," JPEN4, 446-449 (1980).
Barbul et al, "Arginie Stimulates Lymphocyte Immune Response in Healthy Human Beings," Surg., 90, 244-251 (1981).
Barbul et al, "Arginine Stimulates Thymic Immune Function and Ameliorates the Obesity and the Hyperglycemia of Genectically Obese Mice," JPEN,5, 492-495 (1981).
Barbul et al, "Metabolic and Immune Effects of Arginine in Postinjury Hyperalimentation," Journal of Trauma, 21, 970-974 (1981).
Seifter et al, "Arginine: An Essential Amino Acid for Injured Rats," Surg., 84, 224-230 (1978).
Rettura et al, "Arginine Increases the Lymphocyte Content of Thymus Glands," JPEN, 1, Abstract #22A (1977).
Barbul et al, "Arginine (ARG) Improves Thymic Function in OB/OB Mice," JPEN, 4, 589, Abstract #37 (1980).
Barbul et al, "Optimal Levels of Arginine (ARG) in Maintenance IVH," JPEN, 6, 579 (1982).
Barbul et al, "Supplemental Arginine Wound Healing, and Thymus: Arginine-Pituitary Interaction," Surg. Forum, 24, 93-95 (1978).
Barbul et al., "Intravenous Hyperalimentation with High Arginine Levels Improves Wound Healing and Immune Function," J.Surg.Res., 38, 328-334 (1985).
Barbul et al, "Immunostimulatory Effects of Arginine in Normal and Injured Rats," J.Surg.,Res., 29, 228-235 (1980).
Susskind et al, "Regulatory Mechanisms in Cytotoxic T-Lymphocyte Development. II, Dissociation of In Vitro Cytotoxic T-lymphocyte and Suppressor T-Cell Activities with L-Ornithine," Immunochem., 105, #151378s, #553 (1986).
Rettura et al, "Supplemental Arginine Increases Thymic Cellularity in Normal and Murine Sarcoma Virus-inoculated Mice and Increases the Resistance to Murine Sarcoma Virus Tumor," JPEN, 3, 409-416 (1979).
Barbul et al, "Thymic and Immune Stimulatory Actions of Arginine (ARG)," 4th Annual Meeting of the AmericanSociety for Parenteral and Enteral Nutrition, JPEN, 3, 500, #8 (1980).
Barbul et al, "Arginine: A thymotrophic and Wound-Healing Promoting Agent," Surg. Forum 28, 101-103 (1977).
Seifter et al, "Dietary Stimulation of T and B Lymphocyte Dependent Systems," 6th Annual Maine Biomed. Sci. Symp., Jun. 11-13, 1980.
Rettura et al, "Thymic and Wound Healing Actions of Arginine: Abolition by Hypophysectomy",: Am. Chem. Soc. 176th Mtg., Miami Beach, FL, Sep. 10-15, 1978.
Seifter et al, "Arginine (ARG) and Ornithine (ORN) Stimulate Allograft Rejection," Ajinomoto Symp., Amino Acids: Metabolism and Medical Application, Raleigh, NC, Mar. 31-Apr. 2, 1982.
Rettura et al, "Improved Wound Healing, Anti-Catabolic and Thymotropic Actions of Supplemental Ornithine (ORN)," 17th Middle Chem Div., White Haven, PA, Apr. 6-8, 1983.
Seifter et al, "Arginine: Thymotropic Effects," Biol., Abstract #146, Am. Chem. Soc. 174th Mtg., Chicago, IL, Aug. 28-Sep. 2, 1977.
Barbul et al, "High IVH Arginine Levels Improve Wound Healing and Immune Function," Assn. Acad. Surg., San Antonio, TX, Oct. 30-Nov. 3, 1984.
Elsair et al, "Effect of Arginine Chlorhydrate on Nitrogen Balance During the Three Days Following Routine Surgery in Man," Biomed., 29, 312-317 (1978).
Barbul et al, "Arginine and Wound Healing," Fed. Proc., 36, 1099, Abstract #4380 (1977).
"Immun and Metabolic Effects of Arginine in the Surgical Patient," John M. Daly, et al, Department of Surgery, University of Pennsylvania School of Medicine, May 5, 1988.
Flyer entitled "IMPACT," prepared by Sandoz Company of Minneapolis, Minnesota (Sep. 1989).
Wagner et al, "Lipid-Based Parenteral Nutrition and the Immunosuppression of Protein Malnutrition," Arch Surg, vol. 119, Jul. 1984, pp. 809-810.
Neuvonen et al, "Lack of Modulation of Postoperative Immunosuppression by Isotonic Amino Acid Infusion," Journal of Parenteral and Enteral Nutrition, vol. 10, No. 2., pp. 160-165 (Mar.-Apr. 1986).
O'Mahony et al, "The Effect of Short Term Postoperative Intravenous Feeding Upon Cell-Mediated Immunity and Serum Suppressive Activity in Well Nourished Patients," Surgery, Gynecology & Obstetrics, vol. 159, pp. 27-32 (Jul. 1984).
Nuwer et al, "Does Modified Amino Acid Total Parenteral Nutrition Alter Immune-Response in High Level Surgical Stress," Journal of Parenteral and Enteral Nutrition, vol. 7, No. 6, pp. 521-524 (Nov.-Dec. 1983).
Blackburn

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of arginine as an immunostimulator does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of arginine as an immunostimulator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of arginine as an immunostimulator will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-541434

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.