Use of arginase to control nitric oxide formation

Details Use of arginase to control nitric oxide formation Use of arginase to control nitric oxide formation

1990-03-27

1993-03-23

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 941, A61K 3754, A61K 3748

Patent

active

051961954

ABSTRACT:
Reducing plasma levels of endogenous arginine by parenteral administration of arginine depleting agent reduces nitric oxide levels and results in blood pressure increase. Preferably arginase is administered intravenously to raise blood pressure. The arginase can be administered in conjunction with arginine antagonists to potentiate the effect of these. Duration of action and avoidance of antigenicity may be obtained by use in conjunction with a carrier or modifier.

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