Use of antisense oligonucleotides to inhibit the expression...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S375000, C435S377000, C435S006120, C536S023100, C536S024100, C536S024500

Reexamination Certificate

active

07122527

ABSTRACT:
New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.

REFERENCES:
patent: 5958773 (1999-09-01), Monia et al.
Agrawal, Antisense Oligonucleotides: towards clinical trials 1996 Trends Biotechnol. 14: 376-387.
Brazil and Hemmings, Ten years of protein kinas B signalling: a hard Akt to follow 2001 Trends Biochem. Sci. 26: 657-664.
Crooke and Bennett, Progress in Antisense Oligonucleotide Therapeutics 1996 Annu. Rev. Pharmacol. Toxicol. 36:107-29.
Krieg, et al., CpG motifs in bacterial DNA trigger direct B-cell activation 1995 Nature 374: 546-549.
Laptev et al., Specific Inhibition of Expression of a Human Collagen Gene (COLIAI) with Modified Antisense Oligonucleotides. The Most Effective Target Sites are Clustered in Double-Stranded Regions of the Predicted Secondary Structure for the mRNA 1994 Biochemistry 33: 11033-11039.
Stocker, et al., Living with Lethal PIP3 levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB Science, 2002, 295: 2088.
Martin, et al., Ein neuer Zugand zu 2′-0-Alkylribonucleosiden und Eigenschaften deren Oligonucleotide, Helv. Chim. Acta, 1995, 78: 486-504.
Chomczynski, P., and Sacchi, N., Single-Step Method of RNA Isolation by Acid Guanidinum Thiocyanate-Phenol-Chloroform Extraction, Anal. Biochem., 1987, 162: 156-159.
Skehan et al., New Colorimetric Cytoxicity Assay for Anticancer-Drug Screening, J. National Cancer Institute, 1990, 82: 1107-1112.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of antisense oligonucleotides to inhibit the expression... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of antisense oligonucleotides to inhibit the expression..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of antisense oligonucleotides to inhibit the expression... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3695613

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.