Use of antibodies to TNF or fragments derived thereof and xanthi

Details Use of antibodies to TNF or fragments derived thereof and xanthi Use of antibodies to TNF or fragments derived thereof and xanthi

1997-11-10

1999-09-28

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241811, 424 851, 5303871, 53038823, 514263, 514929, A61K 39395, A61K 4505, C07K 1600, A01N 4390

Patent

active

059584130

ABSTRACT:
A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory disorders, which comprises an antibody to TNF or a TNF binding fragment thereof and a xanthine derivative. Particular preferred xanthine derivatives are 3,7-dimethyl-1(5-oxo-hexyl)xanthine (known as Pentoxifylline or TRENTAL) and 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine and similar compounds. The anti-TNF antibody or fragment is preferably monospecific especially a humanized recombinant antibody or fragment.

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