Use of antibodies to intercellular adhesion molecule-1 (ICAM-1)

Details Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) Use of antibodies to intercellular adhesion molecule-1 (ICAM-1)

1993-03-18

1994-06-28

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

53038822, 5303887, 53038885, 5303896, 530866, 530868, A61K 3900, A61K 39395, C02K 1528

Patent

active

053245105

ABSTRACT:
The present invention provides a method of reducing the severity of asthma. Specifically, the present invention discloses that anti-adhesion antibodies, such as anti-ICAM-1 or anti-CD18 family member antibodies, when administered to a mammal, are capable of decreasing the hyperresponsive reaction associated with an asthmatic response.

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Rothlein, R. et al. J. Immunol. 137:1270-4 (1986). "A Human Intracell. Adh. Mol. (ICAM-1) . . . ".
Dustin, M. L. et al. J. Immunol. (1986). vol. 137 (I), pp. 245-254. "Induction by IL-1 and . . . ".
Frigas, E. et al., J. Allergy Clin. Immunol. 77(4):527-537 (1986).
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Wegner, C. D. et al., Science 247:456-459 (1990).

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