Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-06-08
1999-05-04
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 36, 514 37, 514 38, 514 39, 514 40, 514 41, A61K 3170
Patent
active
059004061
ABSTRACT:
The invention described herein provides for methods of screening for compounds that can be used to prevent or inhibit the growth of microbial eukaryotes, particularly plant or animal pathogens. The screening methods of the invention involve the step of screening compounds for the ability to inhibit Group I intron I splicing. In addition, to directly screening for compounds that inhibit Group I intron splicing, the screening methods of the invention include screening for compounds that bind to prokaryotic 16S ribosomal RNA because of the correlation, described herein, between group I intron inhibition and binding to prokaryotic 16S ribosomal RNA. The range of possible compounds for screening by the screening methods of the invention is preferably limited to 2-deoxystreptamine derivatives.
Another aspect of the invention is to provide methods of treating or preventing infections with eukaryotic microbes by administering an effective amount of a compound that inhibits group I intron splicing. These compounds may be obtained by the screening methods of the invention.
REFERENCES:
patent: 2501014 (1950-03-01), Wintersteiner et al.
patent: 2931798 (1960-04-01), Umezana et al.
patent: 3976768 (1976-08-01), Nara et al.
patent: 4029883 (1977-06-01), Hiraga et al.
Davies Julian E.
Schroeder Renee
von Ahsen Uwe
NZYM, Inc.
Peselev Elli
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