Use of anionic detergents with conjugates of monoclonal or polyc

Details Use of anionic detergents with conjugates of monoclonal or polyc Use of anionic detergents with conjugates of monoclonal or polyc

1988-12-22

1992-09-29

Kepplinger, Esther L.

Drug, bio-affecting and body treating compositions

Lymphokine

424 8591, 5303871, 5303881, 5303888, 5303901, 5303917, 530392, 530393, 530403, 530405, 530422, 530828, 530861, 514 2, 514 8, 514 21, 514937, 514975, 252351, A61K 39395

Patent

active

051512661

ABSTRACT:
Methods are disclosed for increasing the solubility of antibodies and their radioisotope, toxin, or drug immunoconjugates and for reducing the non-specific uptake of antibody, either conjugated or unconjugated, into the RES organs such as via Fc receptor-mediated mechanisms. The methods involve incubation of the reactive component with amphipathic molecules, such as an anionic detergent, to achieve the desired result. A preferred anionic detergent in this regard is sodium dodecylsulfate.

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