Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2005-07-26
2005-07-26
LeGuyader, John L. (Department: 1635)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S018000, C800S021000
Reexamination Certificate
active
06921845
ABSTRACT:
Mice that are deficient in p53 are found to have memory disorders and/or behavioral disorders such as increased anxiety. A method of using p53-deficient mice to screen compounds for memory restoring activity and/or anti-anxiety activity is described.
REFERENCES:
patent: 92 11874 (1992-07-01), None
patent: 95 09916 (1995-04-01), None
patent: 95 19367 (1995-07-01), None
Wadhwa et al. J. Biol. Chem. 2002. 277(39) 36665-36670.
Resnick et al. Proc. Nat'l. Acad. Sci. 2003. 100(17)9934-9939.
McGaugh et al., Science, 2000. v287: 248-251.
John Archer, School of Biological Sciences, University of Sussex, Falmer, Brighton, Sussex, England,Tests for Emotionality in Rates and Mice: A Review,Behav., 1973, 21, pp. 205-235.
Roger N. Walsh—Department of Psychiatry and Behavioral Sciences, Stanford University and Robert A. Cummins—Department of Physiology, University of Queensland, Brisbane, Australia,The Open-Field Test: A Critical Review,Psychological Bulletin, 1976, vol. 83, No. 3, pp. 482-504.
Richard G. M. Morris—University of St. Andrews, St. Andrews, Fife, United Kingdom,Spatial Localization Does Not Require the Presence of Local Cues, Learning and Motivation 12, 1981, pp. 239-260.
Richard G. M. Morris—MRC Cognitive Neuroscience Group, Psychological Laboratory, University of St. Andrews, St. Andrews, Fife United Kingdom,Developments of a water-maze Procedure for Studying Spatial Learning in the Rat,Journal of Neuroscience Methods, 11, 1984, pp. 47-60.
Karen Hsiao, Paul Chapman, Steven Nilsen, Chris Eckman, Yasuo Harigaya, Steven Youkin, Fusheng Yang, Greg Cole,Correlative Memory Deficits, AβElevation, and Amyloid Plaques in Transgenic Mice, Science, vol. 274, Oct. 4, 1996, pp. 99-102.
J. Nalbantoglu, G. Tirado-Santiago, A. Lahsaïnl, J. Poirier, O. Goncalves, G. Verge, F. Momoll, S. A. Weiner, G. Massicotte, J.P. Jullen, M. L. Shapiro, Departments of Neurology & Neurosurgery, Psychology, Psychiatry, McGill Centre for Studies in Aging, McGill University, Montreal, Quebec H3A 2B4, Canada, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada, Université du Québec á Trois-Riviéres, Trois-Riviéres, Quebec G9A 5H7, Canada, and Centre for Neuroscience, Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada,Impaired Learning and LTP in Mice Expressing the Carboxy Terminus of the Alzheimer Amyloid Precursor Protein, Nature, vol. 387, May 29, 1997, pp. 500-505.
Pierre Morméde, D.V.M., Ph.D. Laboratoire de Neurogénétique et Stress, INSERM-U471-INRI-Institut Francois Magendie, Bordeaux, France, and Byron C. Jones, Ph.D. (Editor), Department of Biobehavioral Health and Pharmacology, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania,Neurobehavioral Genetics Methods and Applications, Chapter 22, Genetics and Emotional Behaviors—Experimental Studies, Pierre Mormede and Andre Ramos, CRC Press 2000, p. 301-315.
R.T. Gerlai (Editor), South San Francisco, CA, and W.E. Crusio (Editor), Orléans, France,Evaluating Anxiety in Rodents, Techniques in the Behavior and Neural Sciences—Handbook of Molecular-Genetic Techniques for Brain and Behavior Research, Jacqueline N. Crawley, vol. 13, Elsevier 1999, Chapter 4.6, pp. 667-673.
Jean Michel Lassalle and Douglas Waiilsten, Laboratoire d'Ethologie et de Psychophysiologie, Univesite Francois Rabelals, Parc de Grandmont, 37200 Tours, France, and Deparmtne of Pschology, University of Alberta, Edmonton, Alberta, Canada, T6G 2E9, D. Goldowitz (Editor), Memphis, Tennessee, USA, D> Wahlsten (Editor), Edmonton, Alberta, Canada, R>E> Wimer (Editor) Duarte, California, USA,Behavioral Paradigms: General Procedures and Spatial Memory, Techniques for the Genetic Analysis of Brain and Behavior: Focus on the Mouse, Chapter 22, Elsevier 1992, pp. 391-406.
Pierre Morméde, D.V.M., Ph.D. Laboratoire de Neurogénétique et Stress, INSERM-U471-INRI-Institut Francois Magendie, Bordeaux, France, and Byron C. Jones, Ph.D. (Editor), Department of Biobehavioral Health and Pharmacology, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania,Neurobehavioral Genetics Methods and Applications, Chapter 9, Behavioral Phenotyping of Transgenic and Knockout Mice, Jacqueline N. Crawley, CRC Press 2000, p. 105-119.
Jacqueline N. Crawley, Ph.D.,What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,Chapter 6, Learning and Memory, Wiley-Liss 2000, pp. 83-95.
V. Sah et al., Nature Genetics, vol. 10, “A subset of p53-deficient embyros exhibit exencephaly,” pp. 175-180 (1995) XP002101318.
JP Roperch et al., Nature Medicine, vol. 4, No. 7, “Inhibition of presenilin 1 express is promoted by p53 and p21-WAF1 and results in apoptosis and tumor suppression,” pp. 835-838 XP002122379.
YH Jiang et al., Neuron, vol. 21, No. 4, “Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation,” pp. 799-811 (1998) XP002122380.
XP-002101319—Howard K. Gershenfeld et al.: “Mapping Quantitative Trait Loci for Fear-like Behaviors in Mice,” Genomics 46, pp. 1-8 (1997) Academic Press.
Amson Robert
Lassalle Jean-Michel
Telerman Adam
Foley & Lardner LLP
LeGuyader John L.
Molecular Engines Laboratories
Schultz James Douglas
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