Use of angiotensin II fragments and analogs thereof in tissue re

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530316, 530329, A61K 3800

Patent

active

059554304

ABSTRACT:
Angiotensin II fragments and analogs thereof are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.

REFERENCES:
patent: 5015629 (1991-05-01), diZerega
Hunt, T.K. et al., "Coagulation and macrophage stimulation of angiogenesis and wound healing," in The surgical wound, pp. 1-18, ed. F. Dineen & G. Hildrick-Smith (Lea & Febiger, Philadelphia: 1981).
Regoli, D. et al. (1974) Pharmacology of Angiotensin. Pharmacological Reviews, 26:69.
Vatta, MS et al. (1992) Monophasic and biphasic effects of angiotensin II and III on norepinephrine uptake and release in rat adrenal medulla. Can. J. Physiol. Pharmacol. 70:821.
Webb et al. (1992.) Molecular characterization of angiotensin II type II receptors in rat pheochromocytoma cells. Peptides 13:499-508.
Cheng et al. (1994.) Comparison of pressor responses to angiotensin I, II and III in pulmonary vascular bed of cats. Am. J Physiol 266:H2247-H2255.
Moriguchi, A et al. (1994.) Differential regulation of central vasopressin in transgenic rats harboring the mouse Ren-2 gene. Am J Physiol 267:R786-R791. the brain. J Cardiovascular Pharmacol 16(Suppl 4):S19-S243.
Ferrario et al. (1991.) Angiotensin-(1-7): A new hormone of the angiotensin
Benter et al. (1993.) Cardiovascular actions of angiotensin(1-7). Peptides 14:679-684.
Pfeilschifter et al. (1992.) Angiotensin II stimulation of phospholipase D in rat renal mesangial cells is mediated by the AT1 receptor subtype. Eur J Pharmacol 225:57-62.
Jaiswal et al. (1992.) Stimulation of endothelial cell prostaglandin production by angiotensin peptides. Characterization of receptors. Hypertension 19 (Suppl II):II-49-II-55.
Edwards, RM and EJ Stack. (1993.) Angiotensin II inhibits glomerular adenylate cyclase via the angiotensin II receptor subtype 1 (AT1). J Pharmacol Exper Ther 266:506-510.
Jaiswal et al. (1993.) Differential regulation by angiotensin peptides in porcine aortic smooth muscle cells: subtypes of angiotensin receptors involved. J Pharmacol and Exp Therapeutic 265:664-673.
Jaiswal et al. (1991.) Subtype 2 angiotensin receptors mediate prostaglandin synthesis in human astrocytes. Hypertension 17:1115-1120.
Porsti et al. (1994.) Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br. J Pharmacol 111:652-654.
Andreatta-Van Leyen, S et al. (1993.) Modulation of phospholipase A2 activity and sodium transport by angiotensin-(1-7). Kidney International 44:932-6.
Ambuhl et al. 1992. Effects of angiotensin analogues and angiotensin receptor antagonists on paraventricular neurones. Regulatory Peptides 38:111-120.
Holy, Z et al. 1993. Psychotropic effects of angiotensin II N-terminal fragments: Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His in rats. Polish J Pharmacol 45:31-41.
Fitzsimmons, JT. 1971. The effect on drinking of peptide precursors and of shorter chain peptide fragments of angiotensin II injected into the rat's diencephalon. J Physiol 214:295-303.
Wright et al. 1989. Structure-function analyses of brain angiotensin control of pressor action in rats. Am J Physiol 257:R1551-R1557.
Widdop, Robert E. et al. 1992. Electrophysiological Responses of Angiotensin Peptides on the Rat Isolated Nodose Ganglion. Clin and Exper. Hyper.-Theory and Practice, A14(4), 597-613.
Bryson, Susan E. et al. 1992. Induction of the Angiotensin AT2 Receptor Subtype Expression by Differentiation of the Neuroblastoma x Glioma Hybrid, NG-108-15. European Journal of Pharmacology--Molecular Pharmacology Section, 225:119-127.
Janiak, et al. 1992. Role of Angiotensin Subtype 2 Receptor in Neointima Formation After Vascular Injury. Hypertension, 20:737-745.
Gupta, et al. 1995. Locally Generated Angiotensin II in the Adrenal Gland Regulates Basal, Corticotropin-, and Potassium-Stimulated Aldosterone Secretion. Hypertension, 25:443-448.
Mackenzie, et al. 1994. TCV 116 Prevents Progressive Renal Injury in Rats with Extensive Renal Mas Ablation. Journal of Hypertension, 12:(suppl 9):S11-S16.
Viswanathan, et al. 1992. Balloon Angioplasty Enhances the Expression of Angiotensin II AT.sub.1 Receptors in Neointima of Rat Aorta. J. Clin. Invest., 90:1707-1712.
Pratt et al. 1992. The AT2 Isoform of the Angiotensin Receptor Mediates Myointimal Hyperplasia Following Vascular Injury. Hypertension, vol. 20, No. 3, p. 52.
Catalioto et al. 1994. Angiotensins Induce the Release of Prostacyclin from Rabbit Vas Deferens: Evidence for Receptor Heterogeneity. European Journal of Pharmacology 256:93-97.
Speth et al. 1990. Discrimmination of Two Angiotensin II Receptor Subtypes with a Selective Agonist Analogue of Angiotensin II, p-Aminophenylalanine6 Angiotensin II. Biochemical and Biophysical Research Communications, vol. 169, No. 3 997-1006.
Wong et al. 1992. Enhancement of Iosartan (DuP 753)-induced Angiotensin II Receptor Antagonism by PD123177 in Rats. European Journal of Pharmacology, 220:267-270.
Llorens-Cortes et al. 1994. Tissular Expression and Regulation of Type 1 Angiotensin II Receptor Subtypes by Quantitative Reverse Transcriptase-Polymerase Chain Reaction Analysis. Hypertension, 24:538-548.
Wong, 1994. Angiotensin Antagonists in Models of Hypertension. Angiotensin Receptors, pp. 319-336.
Phillips et al. 1994. Angiotensin Receptor Stimulation of Transforming Growth Factor-B in Rat Skin and Wound Healing. Angiotensin Receptors, pp. 377-396.
Prescott et al. 1991. Angiotensin-Converting Enzyme Inhibitor Versus Angiotensin II, AT.sub.1 Receptor Antagonist. Am. J. Pathol. 139:1291-1296.
Harper's Review of Biochemistry, 20th Edition, p. 555 (1985).
Clark, The Experimental Foundations of Modern Immunology, New York, John Wiley & Sons (1983); pp. 13-17.
Ji Ming et al.; Journal of Immunology, vol. 138, 1469-1474 (1987); Tumor Necrosis Factor is Chemotactic for Monocytes and Polymorphonuclear Leukocytes.
Steenfos, et al.; Surgery vol. 106, 171 (1989); Selective effects of tumor necrosis factor-alpha on wound healing in rats.
Lewis et al.; Brain Research, 614 (1993) 1-9; Angiotensin II in the spinal cord of the rat and its sympatho-excitatory effects.
Brattstrom, et al.; Progress in Brain Research; Vo. 91, (1992), pp. 75-79; Neuropeptides within the nucleus tractus solitarii modulate the central cardiovascular control process.
Endocrinology and Metabolism, New York: McGraw-Hill Book Company (1987).
Koelle, The Pharmacological Basis of Therapeutics; London: Collier-MacMillan Limited, (1970); Chapter 23; Parasympathomimetic Agents.
Bell, L., JA Madri, Influence of the Angiotensin System on Endothelial and Smooth Muscle Cell Migration, Am. J. Pathol. vol., 137, No. 1, pp. 7-12 (Jul. 1990).
Bell, L., et al., Autocrine Angiotensin System Regulation of Bovine Aortic Endothelial Cell Migration and Plasminogen Activator Involves Modulation of Proto-oncogene pp60.sup.c-src Expression, J. Clin. Invest., vol. 89, pp. 315-320 (Jan. 1992).
Berk, B.C., et al., Angiotensin II-Stimulated Protein Synthesis in Cultured Vascular Smooth Muscle Cells, Hypertension, vol. 13, No. 4, pp. 305-314 (Apr. 1989).
Berk, B.C., et al., Angiotensin II-Induced Vascular Smooth Muscle Cell Hypertrophy: PDGF A-Chain Mediates the Increase in Cell Size, J. Cell. Physiol., vol. 154, pp. 368-380 (1993).
Campbell-Boswell, M., et al., Effects of Angiotensin II and Vasopressin on Human Smooth Muscle Cells in Vitro, Exp. Mol. Pathol., vol. 35, pp. 265-276 (1981).
Capron, L., et al., Effect of Ramipril, an Inhibitor of Angiotensin Converting Enzyme, on the Response of Rat Thoracic Aorta to Injury with a Balloon Catheter, J. Cardiovasc. Pharmacol., vol. 18, No. 2, pp. 207-211 (1991).
Daemen, M.J.A.P., et al., Angiotensin II Induces Smooth Muscle Cell Proliferation in the Normal and Injured Rat Arterial Wall, Circulation Research, vol. 68, No. 2, pp. 450-456 (Feb. 1991).
Dzau, V.E., et al., Molecular Mechanism of Angiotensin in the Regulation of Vascular and Cardiac Growth, J.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of angiotensin II fragments and analogs thereof in tissue re does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of angiotensin II fragments and analogs thereof in tissue re, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of angiotensin II fragments and analogs thereof in tissue re will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-80247

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.