Use of an in-line filter in the preparation of total nutrient ad

Details Use of an in-line filter in the preparation of total nutrient ad Use of an in-line filter in the preparation of total nutrient ad

1997-01-09

2000-06-13

Kim, John

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210651, B01D 3900, B01D 6100

Patent

active

060745606

ABSTRACT:
A method for reducing the number lipid droplets having a diameter exceeding a preselected threshold in a nutritional emulsion has been developed. The method has the steps of passing the nutritional emulsion, under pressure, through a filter having a pore size smaller than the threshold. A filter having a mean pore size of about 1.2 .mu.m with a standard deviation of about 0.5 is sufficient to exclude lipid droplets having a diameter in excess of five .mu.m.

REFERENCES:
patent: 5252222 (1993-10-01), Matkovich et al.
patent: 5536413 (1996-07-01), Bormann et al.
Puntis, J. et al., "Hazards of parenteral treatment: do particles count?", Arch. Dis. Child., vol. 67, pp. 1475-1477 (1992) .
Driscoll, D.F. et al. "Physiochemical Stability of Total Nutrient Mixtures",Am J Health-Syst Pharm, 52:623-633 (1995).

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