Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "

Details Use of an "immunodeficiency-virus suppressing lymphokine (ISL) " Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "

1997-10-06

1999-11-16

Spector, Lorraine

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4353651, 4352523, 4353201, 424 851, 530351, 536 235, 930141, 935 9, C12N 1519, C07H 2104

Patent

active

059856130

ABSTRACT:
An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is encoded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; or ii) is encoded by DNA sequences which are degenerate to those of SEQ ID NO: 1 or its complement, and nucleic acids encoding said polypeptide. The protein is useful for inhibition of viral replication.

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Immunology, vol. 66, Apr. 1989, pp. 628-630, "A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication". Walker et al.
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