Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Multienzyme complexes or mixtures of enzymes
Patent
1993-06-04
1995-02-21
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Multienzyme complexes or mixtures of enzymes
424 941, 424 943, 424 944, 424 945, 424 946, 424 9461, 424 9462, 424 9463, 424 9464, 424 9465, 424 9466, 424 9467, 424499, 424497, 426 2, 426 63, 426454, 426463, 424499, 424497, A61K 3748
Patent
active
053913710
DESCRIPTION:
BRIEF SUMMARY
The invention comprises a use of an enzyme containing granulate and a method for production of a pelletized fodder.
In the art comprising fodder it is described that the addition of enzymes to the fodder has a beneficial effect, vide e.g. Hesselman, K. and .ANG.man P., The effect of .beta.-glucanase on the utilization of starch and nitrogen by broiler chickens fed on barley of low- or high-viscosity. Animal Feed Science and Technology, 15 (1986) 83-93. Also, in the art comprising fodder it is a well known fact that pelletizing of the fodder is a desideratum, as pelletizing of the fodder increases the digestibility of especially the starch fraction. Furthermore, pelletizing of the fodder reduces the dust, it makes the fodder easier to eat for the birds, and it makes it possible to incorporate small amounts of ingredients in the fodder and to "lock" the fodder mixture. In the process of producing fodder pellets it is considered necessary to heat treat the fodder pellets in order to kill the Salmonella bacteria, whereby a heat treatment to around 80.degree. C. is appropriate. The enzymes are not stable at this high temperature, and thus, a large surplus of enzymes has to be used, or enzyme free fodder components have been pelletized and heat treated, whereafter an enzyme containing slurry or solution has been coated on the heat treated pellets. However, this coating is cumbersome and is often not compatible with existing plants. Thus, there is a need for an enzyme containing fodder which can be produced easier and by means of existing fodder producing plants.
The art encompassing enzyme containing granulates produced as additives in detergents comprises a socalled T-granulate, produced as indicated in U.S. Pat. No. 4,106,991. A T-granulate which is coated with a wax, a triglyceride or other fat, is described in WO 89/08694, claims 12 and 1, EP 206,417, claims 17, 13, and 1, and U.S. Pat. No. 4,707,287, claims 1 and 14 and column 9, example II.
This coated T-granulate has been produced by coating of the T-granulate by a triglyceride instead of the traditional PEG.
The above indicated, coated T-granulate is used as an additive in detergents, and to the best of applicant's knowledge this coated T-granulate has not been suggested for other uses than in the detergent field.
Surprisingly, according to the invention, it has now been found that the above indicated T-granulate can be used as a component of a mixture, which can be converted to a fodder by treatment with steam and pelletizing without appreciable loss of enzyme activity, in contradistinction to the prior art, in relation to which an appreciable loss of enzyme activity will take place during steam treatment and pelletizing.
Thus, the use according to the invention of an enzyme containing T-granulate which is coated with a coating agent comprising a high melting fat or wax, is a use as a component of a mixture, which is well suited as a fodder if the mixture is steam treated and subsequently pelletized.
A T-granulate is a granulate produced according to U.S. Pat. No. 4,106,991, i.e. a granulate containing 2-40% finely divided cellulose fibres. Also, it is to be understood that the T-granulate contains one or more of the enzymes, which can be used as additives to fodders. As typical examples can be mentioned: proteases, e.g. from Bacillus, for instance Bacillus licheniformis, xylanases, cellulases, beta-glucanases, e.g. from Bacillus, Humicola, for instance Humicola insolens, or Actinomycetes, pectinases, e.g. from Aspergillus, .alpha.-galactosidases, e.g. from Aspergillus, for instance Aspergillus niger, and amylases, e.g. from Bacillus, for instance Bacillus subtills.
The coating agent comprises a high melting fat or wax. in this specification with claims a high melting fat is a glycerol ester (mono-, di- or triester or a mixture thereof) with a melting point between 30.degree. and 100.degree. C., and a high melting wax is a waxy substance according to the definition in U.S. Pat. No. 4,106,991, col. 3, lines 45-50, i.e. a substance which possesses all of
Jacobsen Kim T.
Jensen Poul E.
Lowney Karen A.
Novo Nordisk A S
Robinson Douglas W.
Witz Jean C.
Zelson Steve T.
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