Use of an .alpha.-tocopherol phosphate or a derivative thereof f

Details Use of an .alpha.-tocopherol phosphate or a derivative thereof f Use of an .alpha.-tocopherol phosphate or a derivative thereof f

1995-05-30

1999-09-14

Mullis, Jeffrey

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514100, A61K 31355

Patent

active

059520019

ABSTRACT:
The present invention relates to the use of an .alpha.-tocopherol phosphate, especially in its dl or d form, or an ester thereof, of the general formula ##STR1## in which: R.sub.1 is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or an .alpha.-tocopheryl radical; and R.sub.2 is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as methyl or ethyl radical in particular, or an oxyethylene chain of the formula ##STR2## in which R.sub.3 and R.sub.4 independently are a hydrogen atom or a methyl radical and n is an integer greater than or equal to 1, or a salt thereof, for preparing a pharmaceutical, dermatological or cosmetic composition for the prevention or treatment of allergic manifestations such as skin allergy or bronchial asthma, or inflammatory manifestations, or for the prevention or treatment of the harmful effects of free radicals.

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WPIDS AN 91-252, 421 (Bonte et al.).

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