Use of aminothiazoles for treating wounds and skin

Details Use of aminothiazoles for treating wounds and skin Use of aminothiazoles for treating wounds and skin

1999-08-10

2001-03-20

Jarvis, William R. A. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S256000

Reexamination Certificate

active

06204272

ABSTRACT:

BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to the use of substituted 2-aminothiazoles for improving wound healing, and to the use of these compounds for preparing corresponding medicaments.
2. Description of Related Art
From EP-0 365 915, it is already known that such compounds have antimicrobial, in particular strong antibacterial and antimycotic action.
SUMMARY OF THE INVENTION
Surprisingly, it has now been found that these compounds also bring about a considerable improvement in wound healing.
The invention therefore relates to the use of 2-aminothiazoles of the general formula (I).
in which
R
1
represents hydrogen or represents straight-cain or branched alkyl having 1 to 4 carbon atoms and
R
2
represents a radical of the formula
where
R
3
, R
4
, R
5
and R
6
independently of one another each represent hydrogen, fluorine, chlorine, bromine, iodine, nitro, represent in each case straight-chain or branched alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl having in each case 1 to 4 carbon atoms in the respective alkyl moieties or represent in each case straight-chain or branched halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl or halogenoalkylsulphonyl having in each case 1 to 4 carbon atoms and 1 to 9 identical or different halogen atoms—in particular fluorine, chlorine, bromine or iodine,
X represents oxygen, sulphur, sulphinyl or sulphonyl and
Ar represents phenyl, &agr;-naphthyl, &bgr;-naphthyl, tetrahydronaphthyl or indanyl, each of which is optionally mono- or polysubstituted by identical or different substituents, possible substituents being in each case: fluorine, chlorine, bromine, iodine, in each case straight-chain or branched alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl having in each case 1 to 8 carbon atoms in the respective alkyl moieties, in each case straight-chain or branched halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl or halogenoalkylsulphonyl having in each case 1 to 4 carbon atoms and 1 to 9 identical or different halogen atoms, cycloalkyl having 3 to 7 carbon atoms, phenylalkyl or phenoxyalkyl having in each case 1 to 4 carbon atoms in the straight-chain or branched alkyl moiety and also phenyl or phenoxy,
and of their physiologically tolerable acid addition salts for improving wound healing.


REFERENCES:
patent: 4956370 (1990-09-01), Ippen et al.
patent: 5104889 (1992-04-01), Kanai et al.
patent: 5856347 (1999-01-01), Hashiguchi et al.
patent: 38 36 167 (1988-10-01), None
patent: 38 39 758 (1988-11-01), None
patent: 38 36 161 (1990-04-01), None
patent: 365915 (1990-05-01), None
patent: 718296 (1996-06-01), None

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